Publications by authors named "Sophie Morote"
PLoS Negl Trop Dis
October 2020
Article Synopsis
- Histoplasmosis is the leading opportunistic infection and cause of death among HIV patients in French Guiana and Latin America, with rare mucocutaneous lesions often indicating advanced disease.
- A study reviewing HIV-related disseminated histoplasmosis cases from 1981 to 2014 found that 90% of patients were severely immunocompromised, with most not receiving antiretroviral treatment.
- Over time, improvements in diagnosis and treatment led to a significant decrease in the incidence of mucocutaneous lesions and case fatalities, suggesting early diagnosis plays a critical role in managing the disease in South America compared to the USA.
J Fungi (Basel)
August 2020
Article Synopsis
- Histoplasmosis is a major opportunistic infection leading to death among HIV-infected individuals in French Guiana and Latin America, prompting a study comparing cutaneomucous and non-cutaneomucous forms of the disease.
- The study analyzed historical data from 1981 to 2014, revealing that patients with cutaneomucous lesions were more severely immunocompromised and had a higher prior opportunistic infection rate compared to those without such lesions, while also showing fewer digestive symptoms.
- Despite a higher likelihood of diagnosis via direct examination and pathology, patients with cutaneomucous lesions showed a non-significant trend towards higher early mortality risk, indicating a connection between severe immunosuppression and this form of
