Publications by authors named "Sophie M E van Baar de Knegt"
Article Synopsis
- A systematic review and meta-analysis were conducted to evaluate the relationship between low fetal fraction (LFF) in cell-free DNA screening and the risk of fetal chromosomal abnormalities.
- The analysis included 27 studies with over 243,700 singleton pregnancies, showing that LFF is significantly linked to an increased risk of certain conditions like trisomy 13 and 18, but not trisomy 21.
- The review suggests further research is necessary to explore other types of fetal chromosomal issues associated with LFF, highlighting a limitation due to potential bias in how outcomes were assessed across studies.
