Publications by authors named "Sophie Luccantoni"
Article Synopsis
- Early pregnancy Zika virus (ZIKV) infection can cause serious brain damage in fetuses, resulting in conditions like microcephaly, though the exact mechanisms of this damage are still not fully understood.
- A study using cynomolgus macaque fetuses showed that ZIKV was transmitted from infected fetuses to their mothers, leading to detectable viral levels in blood, brain, and placenta, along with signs of brain size reduction in the infected fetuses.
- Despite persistent viral genetic material in tissues, the immune response helped clear much of the virus before the delivery, indicating that while short-term brain injury occurs, the body can partially control the infection.
New Findings: What is the central question of this study? Do Fog2 mice present a defect of small intestine homeostasis? What is the main finding and its importance? The importance of interactions between FOG-2 and pRb in adipose tissue physiology has previously been demonstrated. Here it is shown that this interaction is also intrinsic to small intestine homeostasis and exerts extrinsic control over mouse metabolism. Thus, this association is involved in maintaining small intestine morphology, and regulating crypt proliferation and lineage differentiation.
View Article and Find Full Text PDFThe neurobiological functions of a number of kinases expressed in the brain are unknown. Here, we report new findings on DCLK3 (doublecortin like kinase 3), which is preferentially expressed in neurons in the striatum and dentate gyrus. Its function has never been investigated.
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