Publications by authors named "Sophie Langner-Lemercier"
The frequency of corticospinal tract (CST) T2/FLAIR hyperintensity in disorders with neuroglial antibodies is unclear. Herein, we retrospectively reviewed brain MRIs of 101 LGI1-antibody encephalitis patients, and observed CST hyperintensity in 30/101 (30%). It was mostly bilateral (93%), not associated with upper motor neuron signs/symptoms (7%), and frequently decreased over time (39%).
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- - The study examines the characteristics and outcomes of patients with relapsed or refractory primary CNS lymphoma (PCNSL) who were treated after initial therapy, using data from a French registry between 2011 and 2014.
- - Out of 563 patients receiving first-line treatment, 256 experienced relapse or refractory disease, with those asymptomatic at relapse showing better outcomes, and salvage therapy plus consolidation leading to longer survival.
- - Key factors influencing prognosis include performance status, sensitivity to first-line therapy, the duration of initial remission, and type of management following relapse, highlighting that early relapses generally result in worse outcomes compared to late relapses.
Subthalamic nucleus deep brain stimulation (STN-DBS) has been proven to improve health-related quality of life (HRQoL) in patients with Parkinson's disease (PD) presenting medically refractory motor complications and dyskinesia. However, some patients fail to benefit from STN-DBS despite rigorous preoperative selection. We postulated that they have a particular, clinically ineloquent, brain metabolism before surgery.
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