Publications by authors named "Sophie Lachapelle"
Background: Failure mode, effects, and criticality analysis (FMECA) is a systematic and proactive risk analysis method to determine major failures in complex processes.
Objective: To identify all articles involving the use of failure mode and effects analysis (FMEA), FMECA, or FMECA in health care within the medication use system.
Data Sources Study Selection And Data Extraction: The MEDLINE database was searched, for the period January 1990 to January 2017.
Background: The parenteral nutrition (PN) process is complex and involves multiple steps and substeps, especially in pediatrics and neonatology, given the particular needs of these patients. The objective of this study was to perform a critical analysis of the PN process at the Centre Hospitalier Universitaire Sainte-Justine to determine which potential pitfalls are related to this process and which should be prioritized when implementing corrective measures.
Methods: This is a Failure Mode, Effect, and Criticality Analysis (FMECA) study.
Werner syndrome (WS) is characterized by the premature onset of several age-associated pathologies including cancer. The protein defective in WS patients (WRN) is a helicase/exonuclease involved in DNA replication and repair. Here, we present the results of a large-scale proteome analysis that has been undertaken to determine protein partners of different polymorphic WRN proteins found with relatively high prevalence in the human population.
View Article and Find Full Text PDFWerner syndrome (WS) is a rare disorder characterized by the premature onset of several pathologies associated with aging. The gene responsible for WS codes for a RecQ-type DNA helicase and is believed to be involved in different aspects of DNA repair, replication, and transcription. We recently identified the Scaffold attachment factor B1 (SAFB1) as a potential interactants in human cells.
View Article and Find Full Text PDFArticle Synopsis
- Werner syndrome (WS) involves early onset of aging-related diseases due to a defect in the WRN protein, which plays a key role in DNA repair and maintenance.
- A large-scale proteome study identified 220 proteins interacting with WRN, narrowing down to 40 direct partners after treatment with nucleases during protein extraction.
- Notable new protein interactors include TMPO, HNRNPU, and RPS3, which may be crucial for understanding WRN’s role in preventing aging; the study highlights the importance of using nucleases to refine results in such analyses.
Background: Polybrominated diphenyl ethers (PBDE) are a group of environmental contaminants increasing in North America. Few data are available on neurobehavioral effects at low-dose exposure.
Objectives: Our goal in the present study was to evaluate whether low-dose BDE-47, which is the most abundant PBDE in human samples, affects the neurobehavioral development of rats.