Reduced numbers of circulating group 2 innate lymphoid cells in patients with common variable immunodeficiency.

Recent studies identified an emerging role of group 2 and 3 innate lymphoid cells (ILCs) as key players in the generation of T-dependent and T-independent antibody production. In this retrospective case-control study, CD117 ILCs (including the majority of ILC2 and ILC3) were reduced in patients with common variable immunodeficiency (CVID). The reduction in CD117 ILCs was distinctive to CVID and could not be observed in patients with X-linked agammaglobulinemia.