Publications by authors named "Sophie Gould"
Background And Aims: Blood-based biomarkers for hepatocellular carcinoma (HCC) and its recurrence are lacking. We previously showed that hepatic γ-hydroxy-1, -propano-2'-deoxyguanosine (γ-OHPdG), an endogenous DNA adduct derived from acrolein by lipid peroxidation, increased during hepatocarcinogenesis. Additionally, higher hepatic γ-OHPdG from HCC patients after surgery were strongly associated with poor survival ( < .
View Article and Find Full Text PDFArticle Synopsis
- - Antidepressants, particularly the tricyclic drug amitriptyline (AMI), are widely prescribed, raising concerns about their effects on non-target aquatic organisms like fish due to potential environmental exposure.
- - A study using zebrafish revealed that AMI accumulates in their bodies, converts to an active metabolite, and impacts gene expression related to serotonin transport even at low, environmentally relevant concentrations.
- - While higher concentrations of AMI affected fish behavior (like increased hatch rates and decreased movement), the overall low risk to fish populations may be underestimated due to factors like the ongoing increase in prescription rates and the presence of other drugs acting similarly.
Article Synopsis
- * Most studies indicate that the levels of antidepressants found in nature do not significantly impact fish based on standard risk assessment measures, although some behavioral changes have been observed.
- * There is a need for more research to fill gaps in current data, particularly focusing on long-term effects, behavioral impacts on fish, and exposure to multiple substances, to better understand the risks associated with antidepressants in aquatic ecosystems.