In vitro human skin absorption of ethyl salicylate, pentyl salicylate, and (Z)-3-hexenyl salicylate from topical formulations: Effects on permeation and distribution.

In vitro human skin permeation and distribution of the fragrance materials ethyl salicylate (CAS 118-61-6, ES), (Z)-3-hexenyl salicylate (CAS 65405-77-8, HS) and pentyl salicylate (CAS 2050-08-0, PS) from separate 0.5 % (w/w) cream formulations were determined under unoccluded and occluded conditions for 24 h. For PS only, a 0.