Publications by authors named "Sophie Courbage"
Background: The determinants of early-onset obesity (< 6 years) are not completely elucidated, however eating behavior has a central role. To date no study has explored eating behavior in children with severe, early-onset obesity. Self-administered questionnaire data from these children were examined to evaluate eating behavior and the etiology of early-onset obesity.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the role of heterozygous variants in genes related to severe obesity, specifically focusing on LEP, LEPR, POMC, and PCSK1.
- It analyzed data from 1486 individuals with severe obesity, finding a higher frequency of heterozygous variants compared to homozygous ones, and noted differences in BMI and obesity onset between these groups.
- The findings suggest that heterozygous variants can lead to significant obesity-related phenotypes and highlight the need for targeted genetic analysis in cases of severe early-onset obesity for potential therapeutic strategies.
Long-term outcomes in children undergoing intestinal transplantation remain unclear. Seventy-one children underwent intestinal transplantation in our center from 1989 to 2007. We report on 10-year posttransplant outcomes with (group 1, n = 26) and without (group 2, n = 9) a functional graft.
View Article and Find Full Text PDF