Publications by authors named "Sophie Couderc"
Article Synopsis
- About 20% of neonates with congenital cytomegalovirus (cCMV) experience long-term health issues, making early prediction of outcomes crucial for treatment and counseling.
- The study followed 227 neonates diagnosed with cCMV to identify predictive markers; key findings showed maternal primary infection during the first trimester greatly increased the risk of negative outcomes.
- A model using normal hearing, platelet count, and cranial ultrasound at birth showed high specificity and can help clinicians tailor care for cCMV-affected neonates.
Article Synopsis
- Aicardi-Goutières syndrome (AGS) is an immune-mediated disorder primarily affecting the nervous system, and conventional treatments are largely ineffective.
- A study on JAK1/2 inhibitors showed significant improvement in systemic symptoms of AGS over a median follow-up of 17 months, although neurological benefits were less clear.
- The findings highlight the need for better treatment strategies for AGS's neurological symptoms, emphasizing early diagnosis and potential intrathecal drug delivery for improved outcomes.
Objective: To evaluate cytomegalovirus (CMV) viral load dynamics in blood and saliva during the first 2 years of life in symptomatic and asymptomatic infected infants and to identify whether these kinetics could have practical clinical implications.
Study Design: The Cymepedia cohort prospectively included 256 congenitally infected neonates followed for 2 years. Whole blood and saliva were collected at inclusion and months 4 and 12, and saliva at months 18 and 24.
Article Synopsis
- Cytomegalovirus (CMV) is a leading cause of congenital infections, with around 20% of infected newborns developing sensorineural hearing loss; targeted screening for cCMV in those who fail hearing screening may help identify and treat affected infants early.
- In a study involving 236 newborns in Paris, saliva samples for CMV testing were successfully collected from 98% of participants, showing results within 9 days, and confirming hearing loss in 2.8% of cases.
- The findings indicate that implementing targeted cCMV screening is practical and effective in identifying infected neonates who may benefit from early antiviral treatment.
Background: The known relationship between the gestational age at maternal primary infection an the outcome of congenital CMV is based on small, retrospective studies conducted between 1980 and 2011. They reported that 32% and 15% of cases had sequelae following a maternal primary infection in the first and second or the third trimester, respectively. We aimed to revisit this relationship prospectively between 2011 and 2017, using accurate virological tools.
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- The study addressed gaps in understanding congenital cytomegalovirus (cCMV) by screening 11,715 newborns' saliva for infection, analyzing maternal infection type and sociodemographic factors.
- Results showed a positive predictive value of 59% for CMV PCR, with variations in birth prevalence and risk factors linked to maternal age, previous births, and socioeconomic status.
- The findings highlight the necessity for follow-up confirmation of positive CMV tests and emphasize that seronegative, parous women are at the highest risk for cCMV, suggesting the need for targeted prevention efforts.
Article Synopsis
- The study investigates the effectiveness of high-dosage oral valacyclovir in pregnant women carrying fetuses infected with cytomegalovirus to reduce the risk of neurological impairments.
- A pilot study indicated that valacyclovir could decrease viral load in infected fetuses, but previous trials struggled with recruitment due to women's refusal to participate.
- Results from the study showed promising outcomes, with 8 out of 11 treated women delivering asymptomatic neonates, exceeding the required number for the preliminary success of the trial.
Background: Congenital cytomegalovirus infection occurs in 0.7% of live births with 15-20% of infected children developing long-term disability including hearing loss and cognitive deficit. Fetal cytomegalovirus infection is established by viral DNA amplification by polymerase chain reaction in amniotic fluid obtained by amniocentesis following maternal seroconversion or after the diagnosis of ultrasound features suggestive of fetal infection.
View Article and Find Full Text PDFBackground: Congenital cytomegalovirus (CMV) infection is a public health issue, and implementation of neonatal screening has been debated. Detection of CMV DNA by polymerase chain reaction (PCR) of dried blood spots (DBS) routinely collected for metabolic screening from all newborns has been proposed for congenital CMV infection screening. The goal of this study was to prospectively assess the performance of 2 CMV PCR assays of DBS for CMV neonatal screening in a selected population of neonates.
View Article and Find Full Text PDFObjective: The purpose of this study was to compare neonatal outcome in preterm neonates after twin-to-twin transfusion syndrome (TTTS) that was treated by amnioreduction or fetoscopic laser surgery (FLS) and in dichorionic neonates who were matched for gestational age at birth.
Study Design: Neonatal outcome was assessed in 137 TTTS preterm neonates who were treated primarily with either amnioreduction (n = 36) or FLS (n = 101) and compared with dichorionic twins (n = 242) who were delivered at our center at 24-34 weeks of gestation.
Results: Adverse neonatal outcome (death or severe cerebral lesions) was more frequent in the amnioreduction group than in the FLS and dichorionic groups.
Objective: This study was undertaken to assess the long-term outcome of children born after a first-trimester measurement of nuchal translucency (NT) at the 99th percentile or greater during routine first-trimester screening in an unselected population.
Study Design: One hundred sixty-two infants were born alive. Clinical examination as well as a questionnaire to the parents (Ages and Stages Questionnaires [ASQ]) at the age of 2 years were obtained in 160 children.
Objectives: To determine the incidence and to examine the karyotype and the outcome of fetuses diagnosed with cystic hygroma (CH) at 11-14 weeks of gestation.
Methods: The presence of bilateral cystic anechoic cavities in the neck, nuchal translucency (NT), malformations and hydrops was prospectively recorded in 6894 ultrasound examinations in the first trimester, between 2001 and 2004.
Results: Forty-two fetuses (0.
Objectives: To investigate whether breast feeding is effective for pain relief during venepuncture in term neonates and compare any effect with that of oral glucose combined with a pacifier.
Design: Randomised controlled trial.
Participants: 180 term newborn infants undergoing venepuncture; 45 in each group.