Adult Outcomes of Childhood Wheezing Phenotypes Are Associated with Early-Life Factors.

While the phenotypic diversity of childhood wheezing is well described, the subsequent life course of such phenotypes and their adult outcomes remain poorly understood. We hypothesized that different childhood wheezing phenotypes have varying longitudinal outcomes at age 26. We sought to identify factors associated with wheezing persistence, clinical remission, and new onset in adulthood.

A localized salt-dependent aquagenic urticaria successfully treated with omalizumab.

We present the first case of a localized salt-dependent aquagenic urticaria confirmed by a challenge test. A good therapeutic response was achieved after only the first dose of omalizumab.

Anaphylaxis and Pregnancy: A Systematic Review and Call for Public Health Actions.

Background: Although rare, anaphylaxis during pregnancy implies a risk to both mothers and newborns.

Objective: This systematic review is intended to identify key issues in the diagnosis and management of this condition to support prevention strategies and decrease the risk for death related to anaphylaxis during pregnancy.

Methods: We searched MEDLINE, Cochrane, LILACS, SciELO, and Science Direct databases for manuscripts concerning the term "anaphylaxis during pregnancy," without language restrictions.