Publications by authors named "Sophie C Wehenkel"
Article Synopsis
- L-selectin on T-cells helps naïve and memory cells enter lymph nodes, but it also plays a role in directing activated T-cells to infection sites after being shed.
- Research shows that activated T-cells can re-express L-selectin to locate virus-infected areas, and while the enzyme ADAM17 is crucial for L-selectin's proteolysis, this process does not affect general T-cell activation markers.
- Importantly, L-selectin cleavage enhances the early expansion of cytotoxic T-cells during viral infections, leading to significantly increased immune responses compared to T-cells that can't cleave L-selectin.
The success of adoptive T-cell therapies for the treatment of cancer patients depends on transferred T-lymphocytes finding and infiltrating cancerous tissues. For intravenously transferred T-cells, this means leaving the bloodstream (extravasation) from tumour blood vessels. In inflamed tissues, a key event in extravasation is the capture, rolling and arrest of T-cells inside blood vessels which precedes transmigration across the vessel wall and entry into tissues.
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