Publications by authors named "Sophie Bringer-Deutsch"
Article Synopsis
- The study investigates how hematopoietic stem cell transplantation (HSCT) affects uterus size in women who survived childhood acute leukemia, focusing on the age at HSCT and conditioning type.
- Conducted at 13 French university hospitals, the prospective cohort study included 88 female HSCT survivors compared to a control group, using MRI to measure uterine volume.
- Results showed a significant reduction in uterine volume among HSCT survivors, with those receiving total body irradiation experiencing a 75.3% decrease, compared to a 43.1% decrease in those who received an alkylating agent-based regimen.
Article Synopsis
- Low serum progesterone on frozen embryo transfer day in hormone replacement therapy is linked to poorer reproductive outcomes, prompting a study on "rescue protocols" to improve results.
- The study compared reproductive outcomes in women with low progesterone receiving individualized luteal phase support (iLPS) versus those with adequate levels undergoing pre-implantation genetic testing.
- Results showed a significantly higher ongoing pregnancy rate of 41.03% in the supplemented group compared to 18.60% in the non-supplemented group, indicating the importance of progesterone supplementation for better fertility outcomes.
Article Synopsis
- About 7% of breast cancer cases are diagnosed in women under 40, which raises important questions about fertility preservation options during treatment.* -
- A study of over 15,000 women in France showed that the fertility preservation rate increased to 17% by 2019 but dropped to 13.9% in 2020, with most births occurring through spontaneous pregnancies.* -
- Among women who preserved their fertility, 19.6% had a live birth after treatment compared to only 3.9% in those who did not preserve fertility, indicating significantly better outcomes for the FP group.*
Customized Frozen Embryo Transfer after Identification of the Receptivity Window with a Transcriptomic Approach Improves the Implantation and Live Birth Rates in Patients with Repeated Implantation Failure.
Delphine Haouzi Frida Entezami Antoine Torre Charlène Innocenti Yannick Antoine Sophie Bringer-Deutsch
Reprod Sci
January 2021
Article Synopsis
- The study evaluated the effectiveness of customized embryo transfers (cET) based on a transcriptomic approach (Win-Test) for patients with repeated implantation failure (RIF), involving 217 participants.
- The Win-Test assessed the expression of 11 endometrial genes to determine the optimal receptivity window for embryo transfer, revealing that a significant majority (80%) of patients had receptivity timing that differed from the classical protocol.
- Results showed that pregnancy and live birth rates were significantly higher in the cET group (22.7% and 31.8%) compared to the control group (7.2% and 8.3%), suggesting cET based on Win-Test findings could enhance outcomes for patients with RIF.
Article Synopsis
- - The study compares closed vitrification systems (without direct liquid nitrogen contact) with open systems and aims to report on their effectiveness in egg donation programs.
- - It finds that the number of vitrified oocytes is the main predictor of both survival rates and clinical pregnancy, with a 15% increase in survival odds for each additional oocyte.
- - The outcomes align with established standards, supporting the routine use of closed vitrification systems, but further research with larger sample sizes is needed for broader application.
Article Synopsis
- Several studies indicate a decline in sperm quality over the decades, prompting a study to evaluate how male factors such as sperm quality and paternal age affect IVF and ICSI outcomes.
- The study included data from IVF and ICSI treatments at Montpellier University Hospital from 2010 to 2015, analyzing primary outcomes like blastulation and pregnancy rates, alongside secondary outcomes like fertilization and early miscarriage rates.
- Results showed that severe oligospermia negatively impacted fertilization and blastulation rates, particularly in ICSI, and that paternal age over 51, coupled with maternal age over 37, also reduced pregnancy success rates, suggesting revised fertilization strategies for older couples or those with low sperm quality.
Article Synopsis
- * Using microarrays and RT-qPCR, the research analyzes CCs from women in three different age groups, revealing significant changes in gene expression associated with age.
- * Notably, older patients show increased expression of angiogenic genes and decreased expression of TGF-β signaling genes, with insights into the role of specific microRNAs in regulating these age-related changes.