Time-Restricted Eating and Its Metabolic Benefits.

Newer management strategies are being evaluated to treat obesity, which continues to increase worldwide. After 12 h of fasting, the body switches from glucose to fat metabolism, regulating protein synthesis and autophagy. These cellular responses are central to the metabolic benefits of time-restricted eating (TRE), independent of calorie restriction and weight loss, and they have heightened interest in TRE regimens.

Primary Care Delivery Perceptions and Their Associations with Physician and Patient Gender.

Introduction: We aim to survey patients' opinions on perceived differences in patient care delivered by male and female physicians.

Methods: Patients of primary care practices at Mayo Clinic, Arizona completed a survey sent through the electronic health record. The survey evaluated opinion regarding their primary care physician (PCP)'s overall healthcare provision capabilities and any perceived differences based on gender.

Is your patient at risk for NAFLD?

Nonalcoholic fatty liver disease (NAFLD) affects approximately 37% of US adults. The progression from nonalcoholic fatty liver with no inflammation to steatohepatitis with inflammation and progressive fibrosis is associated with substantial morbidity and mortality. The epidemic of NAFLD requires that primary care providers recognize at-risk patients and screen them.

Hepatitis C Testing and Liver Fibrosis Predictors in the Birth Cohort of a Primary Care Practice.

Objective: To determine the prevalence of and risk factors for advanced fibrosis in patients born from 1945 through 1965 (birth cohort) who underwent testing for hepatitis C virus (HCV).

Patients And Methods: Data were extracted from the electronic health record of all patients receiving primary care at a single academic institution who underwent HCV testing between September 8, 2010, and March 5, 2018. The birth cohort patients were the primary focus of the study.

Pharmacotherapy for obesity: What you need to know.

Weight-loss drugs are being evaluated for their role in obesity management. This article reviews the available weight-loss drugs, their efficacy and side effects, and their best clinical use.

RETROSPECTIVE STUDY OF GLYCEMIC CONTROL FOLLOWING TRANSITION FROM THE INTENSIVE CARE UNIT IN A NATIONAL SAMPLE OF U.S. HOSPITALS.

Objective: Retrospective study to evaluate glycemic control outcomes after transition from the intensive care unit (ICU) to a non-ICU area in a national sample of U.S. hospitals.

Benchmarking glycemic control in u.s. Hospitals.

Objective: Report data on glucose control from 635 U.S. hospitals.

Trends in glycemic control over a 2-year period in 126 US hospitals.

Background: Cross-sectional data on inpatient glucose control in a large sample of US hospitals are now available, but little is known about changes in glycemic control over time in these institutions.

Objective: To evaluate trends in glycemic control in US hospitals over 2 years.

Design: Retrospective analysis.

A sensitive high throughput ELISA for human eosinophil peroxidase: a specific assay to quantify eosinophil degranulation from patient-derived sources.

Quantitative high throughput assays of eosinophil-mediated activities in fluid samples from patients in a clinical setting have been limited to ELISA assessments for the presence of the prominent granule ribonucleases, ECP and EDN. However, the demonstration that these ribonucleases are expressed by leukocytes other than eosinophils, as well as cells of non-hematopoietic origin, limits the usefulness of these assays. Two novel monoclonal antibodies recognizing eosinophil peroxidase (EPX) were used to develop an eosinophil-specific and sensitive sandwich ELISA.

An outpatient-based clinical program for diabetes prevention: an update.

Objective: To update outcomes of the Diet-Exercise-Activity-Lifestyle (DEAL) program, a clinic-based diabetes prevention intervention.

Methods: Changes in weight, fasting blood glucose, and 2-hour glucose after a 75-g oral glucose tolerance test were evaluated in patients who enrolled in the DEAL program between January 2007 and August 2009.

Results: The 221 qualified participants had a mean age of 62 years, weight of 87.

Hemoglobin A1c testing alone does not sufficiently identify patients with prediabetes.

Whether hemoglobin A(1c) (HbA(1c)) values are suitable for diagnosing diabetes has been debated. We sought to assess the prevalence of elevated HbA(1c) levels in a prediabetes patient population. Oral glucose tolerance tests and HbA(1c) levels were analyzed for patients entering a diabetes prevention program between January 1, 2007, and September 13, 2009.

An outpatient-based clinical program for type 2 diabetes prevention.

Objective: To review first-year results of a clinic-based type 2 diabetes prevention program.

Methods: From January through December 2007, patients with a diagnosis of prediabetes participated in the Diet-Exercise-Activity-Lifestyle program for instruction in lifestyle changes. Physical therapy assessments were retrospectively reviewed to search for symptoms or findings of physical impairments.