Publications by authors named "Sophie Ajjan"
Article Synopsis
- Researchers found a specific region in mice that temporarily maintains DNA methylation patterns from the mother after fertilization, influencing gene expression in early development.
- This methylation loss occurs at implantation but stays in some extraembryonic tissues, leading to unique expression of the Zdbf2 gene, particularly in pluripotent cells.
- The study highlights how this dynamic imprinting process impacts gene dosage regulation and development, showing parallels in humans and emphasizing its evolutionary significance.
Identifying loci with parental differences in DNA methylation is key to unraveling parent-of-origin phenotypes. By conducting a MeDIP-Seq screen in maternal-methylation free postimplantation mouse embryos (Dnmt3L-/+), we demonstrate that maternal-specific methylation exists very scarcely at midgestation. We reveal two forms of oocyte-specific methylation inheritance: limited to preimplantation, or with longer duration, i.
View Article and Find Full Text PDFDNA methyltransferases (DNMTs) are responsible for DNA methylation, an epigenetic modification involved in gene regulation. Families of conjugates of procainamide, an inhibitor of DNMT1, were conceived and produced by rapid synthetic pathways. Six compounds resulted in potent inhibitors of the murine catalytic Dnmt3A/3L complex and of human DNMT1, at least 50 times greater than that of the parent compounds.
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