Publications by authors named "Sophia Wells"
Article Synopsis
- High-dose methotrexate (MTX) can lead to serious complications like acute kidney injury (AKI), neutropenia, and liver damage, but glucarpidase, an enzyme that breaks down MTX, shows potential benefits.
- In a study of 708 patients with MTX-AKI across 28 cancer centers, those receiving glucarpidase had a significantly higher chance of kidney recovery and faster recovery times compared to those who did not receive the treatment.
- Additionally, glucarpidase treatment was associated with lower rates of severe neutropenia and liver enzyme elevation, but there was no notable difference in mortality rates between the two groups.
Objective: To develop and externally validate a prediction model for severe cisplatin associated acute kidney injury (CP-AKI).
Design: Multicenter cohort study.
Setting: Six geographically diverse major academic cancer centers across the US.
We used the information component (IC), a disproportionate Bayesian analysis comparing the number of observed versus expected adverse drug reactions, to determine the potential association between anti-neoplastic agents and thrombotic microangiopathy (TMA). The IC indicates the lower end of 95% of IC, in which a value >0 suggests a disproportionality signal between the drug of interest and the adverse drug reaction. Carfilzomib had the highest IC for TMA among all studied chemotherapies followed by gemcitabine, mitomycin, bevacizumab, and bortezomib.
View Article and Find Full Text PDFIntroduction: Hyperthermic intraoperative cisplatin (HIOC) is associated with acute kidney injury (AKI). Administration of high-dose magnesium attenuates cisplatin-induced AKI (CP-AKI) in animal models but has not been rigorously examined in humans.
Methods: We tested the feasibility and safety of different doses of magnesium in mesothelioma patients receiving HIOC.
Article Synopsis
- * The research found that 33.4% of patients experienced AKI within 30 days of transplantation, with certain factors like high levels of rapamycin, specific drug combinations, and lower blood albumin and hemoglobin levels significantly increasing the risk.
- * Additionally, the study evaluated the impact of periengraftment
Article Synopsis
- Researchers are investigating non-invasive biomarkers to diagnose immune checkpoint inhibitor-associated acute tubulointerstitial nephritis (ICI-nephritis), focusing on markers of immune dysregulation linked to CTLA4 deficiency.
- The study compared sIL-2R levels and cell-based markers from patients with ICI-nephritis against various control groups, revealing that sIL-2R levels were significantly elevated in patients with ICI-nephritis.
- A specific sIL-2R cutoff of 1.75-fold above the normal limit was found to be a strong indicator for diagnosing ICI-nephritis.
Macrophages are key cells in the innate immune system and play a role in a variety of diseases. However, macrophages are terminally differentiated and difficult to manipulate genetically via transfection or through CRISPR-Cas9 gene editing. To overcome this limitation, we provide a simplified protocol for the generation of mouse embryonic stem cells-derived macrophages (ESDM).
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