Publications by authors named "Sophia Uddin"

Article Synopsis
  • Snoring is linked to sleep-disordered breathing (SDB) and can impact cognitive and behavioral outcomes in adolescents, but its effects are less understood compared to younger children.
  • This study used data from the Adolescent Brain Cognitive Development (ABCD) Study, involving over 11,000 participants to analyze how snoring affects cognitive abilities and behavioral problems over a five-year period.
  • Findings revealed a decline in habitual snorers from 6.8% to 3.2% over the study duration; however, snoring was not found to be significantly associated with cognitive impairments or behavioral issues among adolescents.
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Background & Objective: Glomus tympanicum and jugulare tumors are highly vascular and are therefore commonly embolized before surgical resection to prevent intra-operative bleeding. We report a case of facial nerve paralysis after pre-operative embolization for a glomus tympanicum tumor with ethylene vinyl alcohol (EVOH also known as Onyx) embolic agent. We discuss the choice of embolic agent in relation to the risk of this complication and potential management strategies.

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Introduction: Migraines are common and debilitating, and have high direct and indirect costs. They can be difficult to treat, and many patients make use of alternative medicine techniques. One of these is acupuncture applied to locations on the auricle thought to modulate migraine symptoms.

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Article Synopsis
  • The study explores the effectiveness of unilateral neck irradiation for patients with well-lateralized tonsil carcinoma classified as N2b, assessing how nodal characteristics impact patient outcomes.
  • A total of 37 patients were treated, with a high percentage (95%) having p16+ disease, and results showed impressive two-year recurrence-free survival (100%) and overall survival (97%) rates after a median follow-up of 3.9 years.
  • The findings suggest that unilateral treatment is effective with no contralateral recurrence, and the specific nodal features like volume, level, and number do not significantly influence the patients' survival outcomes.
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Oral cavity squamous cell carcinoma (OCSCC) is one of the most common head and neck cancers worldwide. It is well known that risk factors for OCSCC include tobacco and excess alcohol consumption. However, in recent years, OCSCC incidence has been increasing in patients without these traditional risk factors.

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During the early months of the COVID-19 pandemic, when health systems were overwhelmed with surging hospitalizations and a novel virus, many ambulatory patients diagnosed with COVID-19 lacked guidance and support as they convalesced at home. This case report offers insight into the implementation of a telehealth service utilizing third- and fourth-year medical students to provide follow-up to ambulatory patients diagnosed with COVID-19. The service was evaluated using medical student surveys and retrospective chart review to assess the clinical and social needs of patients during the spring of 2020.

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This article was migrated. The article was marked as recommended. COVID-19 has disrupted traditional forms of clinical practice in both inpatient and outpatient settings.

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Adjusting to the vocal characteristics of a new talker is important for speech recognition. Previous research has indicated that adjusting to talker differences is an active cognitive process that depends on attention and working memory (WM). These studies have not examined how talker variability affects perception and neural responses in fluent speech.

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Absolute pitch (AP) judgments, by definition, do not require a reference note, and thus might be viewed as context independent. Here, we specifically test whether short-term exposure to particular intonation contexts influences AP categorization on a rapid time scale and whether such context effects can change from moment to moment. In Experiment 1, participants heard duets in which a "lead" instrument always began before a "secondary" instrument.

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Environmental sounds (ES) can be understood easily when substituted for words in sentences, suggesting that linguistic context benefits may be mediated by processes more general than some language-specific theories assert. However, the underlying neural processing is not understood. EEG was recorded for spoken sentences ending in either a spoken word or a corresponding ES.

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There is debate about how individuals use context to successfully predict and recognize words. One view argues that context supports neural predictions that make use of the speech motor system, whereas other views argue for a sensory or conceptual level of prediction. While environmental sounds can convey clear referential meaning, they are not linguistic signals, and are thus neither produced with the vocal tract nor typically encountered in sentence context.

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The development of type 1 diabetes (T1D) is driven by autoreactive T cells that attack and destroy the insulin-producing β-cells in pancreatic islets, forcing patients to take multiple daily insulin injections. Insulin therapy, however, is not a cure and diabetic patients often develop serious long-term microvascular and cardiovascular complications. Therefore, intensive efforts are being directed toward developing safe immunotherapy for the disease that does not impair host defense and preserves β-cells, leading to better glycemic control than exogenous insulin therapy.

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Type 1 diabetes mellitus (T1D) is an autoimmune disease caused by the destruction of pancreatic insulin-producing β cells by autoreactive T cells early in life. Despite daily insulin injections, patients typically develop cardiovascular and other complications; and intensive efforts are being directed toward identifying therapeutic targets to prevent the disease without directly impinging on the host defense. Fas ligand (FasL) is one potential target.

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