Publications by authors named "Sophia Stevens"
Article Synopsis
- The melanocortin-4 receptor (MC4R) plays a key role in regulating energy balance and is a significant target for obesity treatments.
- Researchers determined the structure of the human MC4R when bound to the antagonist SHU9119, revealing a cofactor (calcium) that enhances receptor interactions.
- The study demonstrates that MC4R operates through a unique signaling mechanism, different from traditional G protein-coupled receptors, and shows greater structural similarity to lipidic than peptidic GPCRs.
Objective: To analyze the infection outbreaks, control measures and outcomes of the outbreak in the NICU of a tertiary care centre in the year 2018.
Methods: This study was conducted in a 30 bedded tertiary care NICU from January 2018 through December 2018. The study design was an Outbreak investigation, based on a program of prospective surveillance for nosocomial infection.