Publications by authors named "Sophia Spaia"
Introduction: Management of the Primary Membranous Nephropathy (PMN) usually involves administration of immunosuppressives. Cyclophosphamide (Cyclo) and Calcineurin Inhibitors (CNIs) are both widely used but only limited data exist to compare their efficacy in long term follow-up.
Aim: The aim of the present study was to estimate and compare long term effects of Cyclo and CNIs in patients with PMN.
Article Synopsis
- The study looked at how to diagnose and treat a kidney disease called primary membranous nephropathy (PMN) by examining specific features in kidney samples.
- Researchers analyzed the samples from 752 patients to see how conditions like focal segmental sclerosis (FSGS) and tubular atrophy (TA) affected kidney health.
- They found that certain conditions in the kidneys could predict how well they would function and help decide if patients needed special immune-suppressing treatments.
Background: Sodium sensitivity (SS) and insulin resistance (IR) might be a common link in the pathogenesis of essential hypertension. The aim of the present study is to investigate the relationship, if any, between SS and IR in a population with a family predisposition to develop hypertension.
Methods: Twenty normotensive subjects aged 20 to 40 years with a family history of hypertension (1 or both parents hypertensive) and no other risk factor (group A) and 10 normotensive subjects aged 20 to 40 years without a family history of hypertension (group B) were enrolled.