Publications by authors named "Sophia Silas"
Identifying risk factors for impaired oral rotavirus vaccine (ORV) efficacy in low-income countries may lead to improvements in vaccine design and delivery. In this prospective cohort study, we measure maternal rotavirus antibodies, environmental enteric dysfunction (EED), and bacterial gut microbiota development among infants receiving two doses of Rotarix in India (n = 307), Malawi (n = 119), and the UK (n = 60), using standardised methods across cohorts. We observe ORV shedding and seroconversion rates to be significantly lower in Malawi and India than the UK.
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- A study was conducted on Indian infants to explore why oral poliovirus vaccine (OPV) is less effective in low- and middle-income countries compared to high-income ones, focusing on the role of intestinal microbiota.
- Researchers found that the presence of nonpolio enteroviruses (NPEVs) at the time of vaccination reduced the rate of OPV-induced immunity, particularly when these viruses were newly acquired.
- The results indicated that enteric viruses influence OPV response more than the bacterial microbiota, with recently acquired enterovirus infections being more detrimental to vaccine efficacy than persistent ones.