Bacterial amyloid curli activates the host unfolded protein response via IRE1α in the presence of HLA-B27.

serovar Typhimurium (STm) causes gastroenteritis and can progress to reactive arthritis (ReA). STm forms biofilms in the gut that secrete the amyloid curli, which we previously demonstrated can trigger autoimmunity in mice. HLA-B27 is a genetic risk factor for ReA; activation of the unfolded protein response (UPR) due to HLA-B27 misfolding is thought to play a critical role in ReA pathogenesis.

Lactate promotes the biofilm-to-invasive-planktonic transition in serovar Typhimurium via the purine pathway.

serovar Typhimurium (. Typhimurium) infection triggers an inflammatory response that changes the concentration of metabolites in the gut impacting the luminal environment. Some of these environmental adjustments are conducive to .