Clinical Manifestations.

Background: The multisite SuperAging Research Initiative (SRI) was established in 2021 to identify resilience and resistance factors promoting cognitive healthspan through a harmonized multidisciplinary protocol with prospective data collection. The designation of SuperAger is reserved for individuals age 80+ with episodic memory performance that is at least average for those 2-3 decades younger. Research studies of this relatively uncommon phenotype allow for investigations of fundamental importance to the neurobiology of brain aging, resilience, resistance, and avoidance of cognitive decline related to "average aging" and more severe impairments associated with Alzheimer's and related dementias (ADRD).

Healthiness matters: Approach motivation for healthy food in overweight and obese individuals.

It is well documented that approach tendencies for appetitive substances play a role in certain unhealthy patterns of consumption. However, it remains uncertain whether overweight individuals differ from healthy-weight individuals in terms of their tendency to approach unhealthy foods. Thus, the present study aimed to empirically test the hypothesis that overweight individuals are characterised by an elevated behavioural tendency to approach unhealthy food, rather than healthy food, as compared to healthy-weight individuals.

Low- and High-LET Ionizing Radiation Induces Delayed Homologous Recombination that Persists for Two Weeks before Resolving.

Genome instability is a hallmark of cancer cells and dysregulation or defects in DNA repair pathways cause genome instability and are linked to inherited cancer predisposition syndromes. Ionizing radiation can cause immediate effects such as mutation or cell death, observed within hours or a few days after irradiation. Ionizing radiation also induces delayed effects many cell generations after irradiation.