Publications by authors named "Sophia Krasny"
Excessive mitochondrial fragmentation is associated with the pathologic mitochondrial dysfunction implicated in the pathogenesis of etiologically diverse diseases, including many neurodegenerative disorders. The integrated stress response (ISR) - comprising the four eIF2α kinases PERK, GCN2, PKR, and HRI - is a prominent stress-responsive signaling pathway that regulates mitochondrial morphology and function in response to diverse types of pathologic insult. This suggests that pharmacologic activation of the ISR represents a potential strategy to mitigate pathologic mitochondrial fragmentation associated with human disease.
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- - This study examines the link between Down syndrome (DS) and early-onset Alzheimer's disease (AD), focusing on how amyloid positivity, memory function, and clinical status change with age.
- - Data from the Alzheimer Biomarker Consortium-Down Syndrome (ABC-DS) was used to analyze amyloid levels and cognitive function in 409 adults with DS, revealing that both amyloid positivity and memory decline increase significantly as individuals age.
- - The research highlights the need for age-specific considerations in monoclonal antibody trials targeting AD in individuals with DS, as there’s a considerable gap between amyloid detection and visible clinical symptoms.
Article Synopsis
- Excessive fragmentation of mitochondria is linked to various diseases, particularly neurodegenerative disorders, highlighting the importance of maintaining mitochondrial health.
- The integrated stress response (ISR), a signaling pathway that consists of four eIF2α kinases, plays a key role in regulating mitochondrial shape and function under stress conditions.
- Activation of ISR kinases HRI or GCN2 can promote beneficial mitochondrial elongation and counteract fragmentation, suggesting that targeting the ISR might be a viable treatment approach for diseases associated with mitochondrial dysfunction.