Publications by authors named "Sophia Holten"
Am J Pathol
November 2024
Article Synopsis
- Liver fibrosis results from chronic liver inflammation leading to excess extracellular-matrix production by activated hepatic stellate cells (HSCs), which can lead to serious liver damage.*
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- Research on mice showed that lacking HIF-prolyl-hydroxylase 1 (PHD1) reduced liver fibrosis severity and related inflammation, while treatment with the inhibitor DMOG did not prevent fibrosis.*
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- PHD1 deficiency was linked to decreased activation of HSCs and lower expression of fibrotic and inflammatory markers, suggesting that targeted PHD1 inhibitors might be effective in managing liver fibrosis.*
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