The neuronal transcription factor NPAS4 is a strong inducer of sprouting angiogenesis and tip cell formation.

Rationale: Regarding branching morphogenesis, neurogenesis and angiogenesis share common principle mechanisms and make use of the same molecules. Therefore, the investigation of neuronal molecules involved in vascular morphogenesis provides new possibilities for pro-angiogenic approaches in cardiovascular diseases.

Objective: In this study, we investigated the role of the neuronal transcription factor NPAS4 in angiogenesis.