Clear-cell Variant of Mucoepidermoid Carcinoma Presenting as a Palatal Mass in a 10-Year-old Boy.

Background: The clear-cell variant of mucoepidermoid carcinoma (MEC) involving minor salivary glands is extremely rare in children.

Case Report: We report a case of clear-cell variant MEC in the minor salivary gland in a 10-year-old boy who presented with a mass of the right hard palate. Fine-needle aspiration showed features suggestive of clear-cell variant of MEC.

Tophaceous gout of the nose in a male premutation carrier.

Premutation alleles with 55-200 CGG repeats in can lead to fragile X-associated tremor/ataxia syndrome (FXTAS). In this case study, we report uncontrolled gout in a 68-year-old male with FXTAS with multiple sites of involvement including a rare gouty tophus in the nasal region.

Gestational microbiome: metabolic perturbations and developmental programming.

A growing body of research suggests that alterations to the human microbiome are associated with disease states, including obesity and diabetes. During pregnancy, these disease states are associated with maternal microbial dysbiosis. This review discusses the current literature regarding the typical maternal and offspring microbiome as well as alterations to the microbiome in the context of obesity, type 2 diabetes mellitus, and gestational diabetes mellitus.

Combining Electromagnetic and Gravitational-Wave Constraints on Neutron-Star Masses and Radii.

We perform a joint Bayesian inference of neutron-star mass and radius constraints based on GW170817, observations of quiescent low-mass x-ray binaries (QLMXBs), photospheric radius expansion x-ray bursting sources, and x-ray timing observations of J0030+0451. With this dataset, the form of the prior distribution still has an impact on the posterior mass-radius curves and equation of state (EOS), but this impact is smaller than recently obtained when considering QLMXBs alone. We analyze the consistency of the electromagnetic data by including an "intrinsic scattering" contribution to the uncertainties, and find only a slight broadening of the posteriors.

Isometric exercise facilitates attention to salient events in women via the noradrenergic system.

The locus coeruleus (LC) regulates attention via the release of norepinephrine (NE), with levels of tonic LC activity constraining the intensity of phasic LC responses. In the current fMRI study, we used isometric handgrip to modulate tonic LC-NE activity in older women and in young women with different hormone statuses during the time period immediately after the handgrip. During this post-handgrip time, an oddball detection task was used to probe how changes in tonic arousal influenced functional coordination between the LC and a right frontoparietal network that supports attentional selectivity.

Community Partnership in Precision Medicine: Themes from a Community Engagement Conference.

Background: Patient and community engagement in under-resourced communities is a key issue for precision medicine research. We report proceedings from a community-academic partnered conference in Los Angeles to promote community understanding of precision medicine and generate engagement recommendations.

Methods: Planning group review of planning, presentations, and audience discussions from facilitator notes and participant survey data from a one-day conference.