Publications by authors named "Sophia Costa Vasconcelos"
Objective: The present study's objective is to assess whether sleep duration affects Early Childhood Development (ECD). A prospective cohort study was carried out with 278 mother-child dyads in the city of Fortaleza, northeastern Brazil, with data collection every 6 months.
Method: The data used in this study are from the third (18 months) and fourth (24 months) survey waves.
Coverage and determinants of childhood vaccination during the COVID-19 pandemic in Fortaleza, Northeastern Brazil: a longitudinal analysis.
Cad Saude Publica
February 2024
Brazil has seen a decrease in vaccination coverage since 2016. This study analyzes the immunization status of children born during the COVID-19 pandemic in Fortaleza, Northeastern Brazil. This is a longitudinal analysis that included vaccination data of 313 children aged 12 and 18 months.
View Article and Find Full Text PDFPathophysiology and Treatment of Lipid Abnormalities in Cerebrotendinous Xanthomatosis: An Integrative Review.
Brain Sci
June 2023
Article Synopsis
- - Cerebrotendinous xanthomatosis (CTX) is a genetic disorder marked by a deficiency in sterol 27-hydroxylase, leading to dangerous buildups of cholestanol and bile alcohols in the brain, tendons, and nerves.
- - A review of literature highlighted that CTX patients typically show elevated cholestanol levels while having normal or low serum cholesterol levels; this dyslipidemia may indicate increased risk for atherosclerosis and cardiovascular issues.
- - The study suggests the potential use of cholesterol metabolites, like bile alcohols, as follow-up markers for monitoring CTX due to their relationship with abnormal lipid profiles and associated clinical symptoms.
Cerebrotendinous Xanthomatosis represents a rare and underdiagnosed inherited neurometabolic disorder due to homozygous or compound heterozygous variants involving the gene. This bile acid metabolism disorder represents a key potentially treatable neurogenetic condition due to the wide spectrum of neurological presentations in which it most commonly occurs. Cerebellar ataxia, peripheral neuropathy, spastic paraparesis, epilepsy, parkinsonism, cognitive decline, intellectual disability, and neuropsychiatric disturbances represent some of the most common neurological signs observed in this condition.
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