Publications by authors named "Sophia Bowen"
J Clin Endocrinol Metab
November 2024
Article Synopsis
- Peripancreatic adipose tissue (PAT), which accumulates with obesity, negatively affects metabolic health and beta cell function, highlighting its significance compared to subcutaneous adipose tissue (SAT).
- PAT secretes higher levels of inflammatory substances and certain adipokines linked to poor metabolic outcomes, with variations in islet insulin secretion observed between male and female donors.
- RNA sequencing reveals that PAT influences gene transcription and lipid metabolism in islets in a sex-dependent manner, suggesting different metabolic impacts compared to SAT.
