Publications by authors named "Sophia Barry"
Article Synopsis
- Open goals, such as aiming to increase daily steps, have been found to encourage physical activity and positive experiences compared to specific targets like 10,000 steps.
- A study tested the feasibility of an open-goal approach over 10 weeks with 15 adults, focusing on factors like recruitment and adherence, and found high participation along with increased physical activity levels.
- Results suggested that open goals enhance enjoyment and self-efficacy while reducing negative feelings, demonstrating their potential for use in longer-term physical activity programs.
Prior work established that a deficiency in the cysteine protease dipeptidyl peptidase I (DPPI) improves survival following polymicrobial septic peritonitis. To test whether DPPI regulates survival from severe lung infections, DPPI(-/-) mice were studied in a Klebsiella pneumoniae lung infection model, finding that survival in DPPI(-/-) mice is significantly better than in DPPI(+/+) mice 8d after infection. DPPI(-/-) mice have significantly fewer bacteria in the lung than infected DPPI(+/+) mice, but no difference in lung histopathology, lung injury, or cytokine levels.
View Article and Find Full Text PDFEffective host defense requires a robust, yet self-limited response to pathogens. A poorly calibrated response can lead to either bacterial dissemination due to insufficient inflammation or organ injury due to excessive inflammation. Recent evidence suggests that the cholinergic anti-inflammatory reflex helps calibrate the immune response.
View Article and Find Full Text PDFBackground: Stress of the endoplasmic reticulum (ER) leading to activation of the unfolded protein response (UPR) and alveolar epithelial cell (AEC) apoptosis may play a role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Our objectives were to determine whether circulating caspase-cleaved cytokeratin-18 (cCK-18) is a marker of AEC apoptosis in IPF, define the relationship of cCK-18 with activation of the UPR, and assess its utility as a diagnostic biomarker.
Methods: IPF and normal lung tissues were stained with the antibody (M30) that specifically binds cCK-18.