Single-dose oral challenges to validate eliciting doses in children with cow's milk allergy.

Background: There is increasing interest in the use of eliciting doses (EDs) to inform allergen risk management. The ED can be estimated from the distribution of threshold doses for allergic subjects undergoing food challenges within a specified population. Estimated ED values for cow's milk (the dose expected to cause objective allergic symptoms in 5% of the milk-allergic population) range from 0.