Publications by authors named "Sooyun Lee"
ErbB3 is markedly overexpressed in breast cancer cells and is associated with resistance and metastasis. Additionally, ErbB3 expression levels are positively correlated with low densities of tumor-infiltrating lymphocytes, a marker of poor prognosis. Consequently, ErbB3 is a promising therapeutic target for cancer immunotherapy.
View Article and Find Full Text PDFEffects of amoxicillin/clavulanic acid on the pharmacokinetics of valproic acid.
Drug Des Devel Ther
June 2016
Valproic acid (VPA) is mainly metabolized via glucuronide, which is hydrolyzed by β-glucuronidase and undergoes enterohepatic circulation. Amoxicillin/clavulanic acid (AMC) administration leads to decreased levels of β-glucuronidase-producing bacteria, suggesting that these antibiotics could interrupt enterohepatic circulation and thereby alter the pharmacokinetics of VPA. This study aimed to evaluate the effects of AMC on the pharmacokinetics of VPA.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to compare the pharmacokinetics (how the drug moves in the body), pharmacodynamics (how the drug affects the body), and safety of controlled-release (CR) versus immediate-release (IR) formulations of sarpogrelate after administering multiple doses.
- Conducted with healthy participants, the research involved administering CR sarpogrelate once daily and IR sarpogrelate three times daily, followed by thorough blood sampling to analyze drug behavior and effects on platelet aggregation.
- Results indicated that CR sarpogrelate had a slightly higher overall exposure time and similar peak concentrations compared to IR, while both formulations exhibited comparable effects on platelet aggregation and safety profiles.
A fixed-dose combination of amlodipine and olmesartan is used to treat high blood pressure in patients whose hypertension is not sufficiently controlled with either drug alone. The objective of this study was to evaluate the bioequivalence of two fixed-dose combinations, ie, amlodipine orotate/olmesartan medoxomil 10/40 mg and amlodipine besylate/olmesartan medoxomil 10/40 mg, in healthy subjects. A randomized, open-label, single-dose, two-sequence, two-period, crossover study was conducted in 30 healthy adult volunteers.
View Article and Find Full Text PDFPurpose: Valsartan, an angiotensin-receptor blocker, and rosuvastatin, a competitive inhibitor of the 3-hydroxy-3-methylglutaryl coenzyme A reductase, are frequently coadministered to treat patients with hypertension and dyslipidemia. The study reported here sought to evaluate the pharmacokinetic and pharmacodynamic interactions between rosuvastatin and valsartan in healthy Korean subjects.
Subjects And Methods: Thirty healthy male Korean subjects were administered with rosuvastatin (20 mg/day), valsartan (160 mg/day), and both drugs concomitantly for 4 days in a randomized, open-label, multiple-dose, three-treatment, three-period crossover study.
Aims: Lobeglitazone has been developed for the treatment of type 2 diabetes mellitus. This study was conducted to evaluate potential drug-drug interactions between lobeglitazone and warfarin, an anticoagulant with a narrow therapeutic index.
Methods: In this open-label, three-treatment, crossover study, 24 healthy male subjects were administered lobeglitazone (0.