Publications by authors named "Sooyeon Jeon"
Standardization and quality assessment for human intestinal organoids.
Front Cell Dev Biol
September 2024
To enhance the practical application of intestinal organoids, it is imperative to establish standardized guidelines. This proposed standardization outlines a comprehensive framework to ensure consistency and reliability in the development, characterization, and application of intestinal organoids. The recommended guidelines encompass crucial parameters, including culture conditions, critical quality attributes, quality control measures, and functional assessments, aimed at fostering a standardized approach across diverse research initiatives.
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- * Despite its promise, there's significant variability in how organoids are produced across labs, leading to low reproducibility and a lack of standardized quality evaluation.
- * To address these issues, South Korea launched the Organoid Standards Initiative in September 2023, creating general guidelines for organoid manufacturing and evaluation to enhance consistency and regulatory acceptance.
Article Synopsis
- The paper outlines guidelines for managing the packaging, storage, transportation, and traceability of source cells crucial for organoid research, aiming to ensure their quality and integrity throughout the process.
- It emphasizes the importance of a cohesive strategy to prevent contamination and deterioration, which can compromise the safety and effectiveness of the source cells.
- The guidelines include quality control measures across the supply chain, recommending specific practices for packaging, transport, and storage, and stress the need for an integrated management system to enhance global sharing and utilization of source cells in research.