Particle-Filter-Based Fault Diagnosis for the Startup Process of an Open-Cycle Liquid-Propellant Rocket Engine.

This study introduces a fault diagnosis algorithm based on particle filtering for open-cycle liquid-propellant rocket engines (LPREs). The algorithm serves as a model-based method for the startup process, accounting for more than 30% of engine failures. Similar to the previous fault detection and diagnosis (FDD) algorithm for the startup process, the algorithm in this study is composed of a nonlinear filter to generate residuals, a residual analysis, and a multiple-model (MM) approach to detect and diagnose faults from the residuals.

Numerical study on advective fog formation and its characteristic associated with cold water upwelling.

Recent rapid industrial development in the Korean Peninsula has increased the impacts of meteorological disasters on marine and coastal environments. In particular, marine fog driven by summer cold water masses can inhibit transport and aviation; yet a lack of observational data hinders our understanding of this phenomena. The present study aimed to analyze the differences in cold water mass formation according to sea surface temperature (SST) resolution and its effects on the occurrence and distribution of sea fog over the Korean Peninsula from June 23-July 1, 2016, according to the Weather Research and Forecasting model.

Stable maintenance of the Mre11-Rad50-Nbs1 complex is sufficient to restore the DNA double-strand break response in cells lacking RecQL4 helicase activity.

The proper cellular response to DNA double-strand breaks (DSBs) is critical for maintaining the integrity of the genome. RecQL4, a DNA helicase of which mutations are associated with Rothmund-Thomson syndrome (RTS), is required for the DNA DSB response. However, the mechanism by which RecQL4 performs these essential roles in the DSB response remains unknown.

Numerical simulation of atmospheric CO2 concentration and flux over the Korean Peninsula using WRF-VPRM model during Korus-AQ 2016 campaign.

We conducted regional scale CO2 simulations using the Weather Research and Forecasting model (WRF) coupled with the Vegetation Photosynthesis and Respiration Model (VPRM). We contrasted simulated concentrations with column, ground and aircraft observations during the Korea-United States Air Quality (KORUS-AQ) 2016 field campaign. Overall, WRF-VPRM slightly underestimates CO2 concentrations at ground and column monitoring sites, but it significantly underestimates at an inland tower measurement site, especially within the stable (nocturnal) boundary layer in nighttime.

Relation Modeling of Factors Influencing Life Satisfaction and Adaptation of Korean Older Adults in Long-Term Care Facilities.

This study aimed to model and examine the relationship between the factors influencing the adaptation ability and life satisfaction of the elderly people living in long-term care facilities. This study used a cross-sectional descriptive design and relation prediction modeling. Participants were 229 older adults over 65 years old, who had lived for more than six months in the long-term care facilities of the Gyeonggi and Gyeongsang provinces, South Korea.

Effects of health promoting education program for Korean middle-aged women.

[Purpose] This study aimed to examine the effects of health promoting education program on self-efficacy, health promoting behavior, and quality of life of Korean middle-aged women. [Participants and Methods] Participants were total 60 women (experimental: n=30, control: n=30) in the age group of 40-59, who visit community center located at G gu in Seoul. Health promoting education program was performed for 6 weeks, once a week, one hour with 20 minute group discussion.

ATM activation is impaired in human cells defective in RecQL4 helicase activity.

RecQL4 has been shown to be involved in DNA replication and repair, but its role in DNA damage checkpoint pathway has not been reported. Here, we show that RecQL4 plays an important role in the activation of ataxia telangiectasia mutated (ATM)-dependent checkpoint pathway in human cells. Cells depleted with RecQL4 or Rothmund-Thomson syndrome cells showed significant impairment in the activation of ATM and the downstream effector proteins such as checkpoint kinase 2 and p53 after DNA damage.

Lung function in patients with lung injury due to household chemical inhalation: Post hoc analysis of a prospective nationwide cohort.

Background And Objective: Inhalation exposure to household chemicals can result in serious health problems, although the long-term outcomes are unclear. We evaluated the changes in lung function after home humidifier disinfectant (HD) exposure.

Methods: This post hoc analysis of a prospective nationwide cohort involved patients with inhalation lung injury due to HD.

Selective self-assembly of adenine-silver nanoparticles forms rings resembling the size of cells.

Self-assembly has played critical roles in the construction of functional nanomaterials. However, the structure of the macroscale multicomponent materials built by the self-assembly of nanoscale building blocks is hard to predict due to multiple intermolecular interactions of great complexity. Evaporation of solvents is usually an important approach to induce kinetically stable assemblies of building blocks with a large-scale specific arrangement.

RecQL4 is required for the association of Mcm10 and Ctf4 with replication origins in human cells.

Though RecQL4 was shown to be essential for the initiation of DNA replication in mammalian cells, its role in initiation is poorly understood. Here, we show that RecQL4 is required for the origin binding of Mcm10 and Ctf4, and their physical interactions and association with replication origins are controlled by the concerted action of both CDK and DDK activities. Although RecQL4-dependent binding of Mcm10 and Ctf4 to chromatin can occur in the absence of pre-replicative complex, their association with replication origins requires the presence of the pre-replicative complex and CDK and DDK activities.

Ligand-assisted etching: the stability of silver nanoparticles and the generation of luminescent silver nanodots.

The etching mechanism of silver nanoparticles was investigated. Though a strong binding agent to silver and an oxidising agent synergistically etch the nanoparticles, the balanced etching power has to be optimized to generate luminescent silver nanodots. This indicates that active centres facilitate the formation of nanodots.

Abdominal compartment syndrome in severe acute pancreatitis treated with percutaneous catheter drainage.

Acute pancreatitis is one of the main causes of intra-abdominal hypertension (IAH). IAH contributes to multiple physiologic alterations and leads to the development of abdominal compartment syndrome (ACS) that induces multiorgan failure. We report a case of ACS in a patient with severe acute pancreatitis.

A case of choledocholithiasis and intestinal malrotation in an adolescent with repaired gastroschisis.

Most infants with repaired gastroschisis develop normally and remain in good health. About 10% of patients with gastroschisis have other malformations. We report a case of choledocholithiasis and intestinal malrotation in an adolescent with repaired gastroschisis.

DNA-encapsulated silver nanodots as ratiometric luminescent probes for hypochlorite detection.

Unlabelled: DNA-encapsulated silver nanodots are noteworthy candidates for bio-imaging probes, thanks to their excellent photophysical properties. The spectral shift of silver nanodot emitters from red to blue shows excellent correlations with the concentration of reactive oxygen species, which makes it possible to develop new types of probes for reactive oxygen species (ROS), such as hypochlorous acid (HOCl), given the outstanding stability of the blue in oxidizing environments. HOCl plays a role as a microbicide in immune systems but, on the other hand, is regarded as a disease contributor.

Oxidant-resistant imaging and ratiometric luminescence detection by selective oxidation of silver nanodots.

Reactive oxygen species selectively accelerated transitions between various silver nanodots. The blue was developed as an oxidant-resistant imaging agent and analyte reporter. In addition to the spectral response of nanodots to ROS, silver nanodots were formulated to detect analytes with excellent selectivity and picomolar detection limit when coupled to glucose oxidase.

Acute Profound Thrombocytopenia after Using Abciximab for No-Reflow during Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction.

Glycoprotein IIb/IIIa antagonists are well established for their effectiveness in improving clinical outcomes in acute coronary syndrome patients undergoing percutaneous coronary intervention. Acute profound thrombocytopenia is a rare complication of abciximab. We present a case which was managed successfully for the rare complication of acute profound thrombocytopenia after using abciximab and an intra-aortic balloon pump for the treatment of a no-reflow phenomenon and consecutive cardiogenic shock during primary percutaneous coronary intervention.

microRNA-101 inhibits lung cancer invasion through the regulation of enhancer of zeste homolog 2.

microRNAs (miRNAs) may function as oncogenes or tumor-suppressor genes depending on the targets that are regulated. Enhancer of zeste homolog 2 (EZH2) is the target of miR-101 and a member of the polycomb repressive complex 2, which is involved in the methylation of histone H3 at lysine 27 (H3K27). Therefore, we aimed to ascertain whether or not the overexpression of miR-101 inhibits invasion of lung cancer through regulation of EZH2.

Segmentation of interest region in medical volume images using geometric deformable model.

In this paper, we present a new segmentation method using the level set framework for medical volume images. The method was implemented using the surface evolution principle based on the geometric deformable model and the level set theory. And, the speed function in the level set approach consists of a hybrid combination of three integral measures derived from the calculus of variation principle.

Mimosine arrests the cell cycle prior to the onset of DNA replication by preventing the binding of human Ctf4/And-1 to chromatin via Hif-1α activation in HeLa cells.

Though the G(1) checkpoint in mammalian cells has been known for decades, the molecular targets that prevent S-phase entry remain unknown. Mimosine is a rare plant amino acid that arrests the cell cycle in the G(1) phase before entry into S phase. Here, we show that mimosine interrupts the binding of Ctf4 to chromatin, which is essential for the initiation of DNA replication in HeLa cells, and this effect is mediated by the Hif-1α-dependent increase in the level of p27.

Comparative genomics of the mating-type loci of the mushroom Flammulina velutipes reveals widespread synteny and recent inversions.

Background: Mating-type loci of mushroom fungi contain master regulatory genes that control recognition between compatible nuclei, maintenance of compatible nuclei as heterokaryons, and fruiting body development. Regions near mating-type loci in fungi often show adapted recombination, facilitating the generation of novel mating types and reducing the production of self-compatible mating types. Compared to other fungi, mushroom fungi have complex mating-type systems, showing both loci with redundant function (subloci) and subloci with many alleles.

Composition and proposed structure of a water-soluble glycan from the Keumsa Sangwhang Mushroom (Phellinus linteus).

Phellinus linteus is a mushroom which has been prized in Korea for its medicinal properties since ancient times. A glycan preparation from this source has shown promise in experimental anti-tumour and metastasis studies, but the glycan has not been well characterized. In the present work, the glycan fraction of a hot water extract from P.