Publications by authors named "Soonhyuck Ok"
Background: Activating transcription factor 4 (ATF4) is a fundamental basic-leucine zipper transcription factor that plays a pivotal role in numerous stress responses, including endoplasmic reticulum (ER) stress and the integrated stress response. ATF4 regulates adaptive gene expression, thereby triggering stress resistance in cells.
Methods: To characterize the metabolic status of larvae, we conducted both metabolomic and microarray analyses.
Article Synopsis
- * A study using a Drosophila ADRP model identified the Wg/Wnt1 pathway as a key mediator of apoptosis in response to ER stress, highlighting the importance of this signaling route.
- * Researchers discovered that the serine protease Erasp, regulated by the Wg/Wnt1 pathway, can either promote or suppress apoptosis, suggesting it could be a potential target for treating retinal degeneration associated with mutant rhodopsin.