Publications by authors named "Soon-Sil Hyun"
Inhibitory Effect of Chlorogenic Acid Analogues Comprising Pyridine and Pyrimidine on α-MSH-Stimulated Melanogenesis and Stability of Acyl Analogues in Methanol.
Pharmaceuticals (Basel)
November 2021
Article Synopsis
- A new series of chlorogenic acid (CGA) analogues, including pyridine, pyrimidine, and diacyl derivatives, were designed and synthesized to inhibit melanogenesis stimulated by α-MSH.
- Out of nineteen compounds tested, fifteen showed improved inhibition of melanin production in B16 melanoma cells, with a specific pyridine analogue and a diacyl derivative demonstrating the strongest inhibition rates.
- Structure-activity relationship (SAR) studies revealed that certain substituents on the benzylamine group contributed to better inhibition, while the stability of diacyl analogues in methanol highlighted that the size of acyl groups affects their stability over time.
For the systematic SAR study on mansonone F, a series of C6 and C9 analogs of mansonone F have been synthesized and their anti-MRSA activities were evaluated. Most of the analogs exhibited good or excellent anti-MRSA activities. In particular, the 6-n-butylmansonone F showed fourfold higher antibacterial activities compared to that of vancomycin.
View Article and Find Full Text PDFSyntheses and excellent anti-MRSA activities of the mansonone F analogs are reported. In addition, the minimal structural requirements for its anti-MRSA activities as well as its structure-activity relationship including the C3 substituents effects on anti-MRSA activity are also described. In particular, this study revealed that both ortho-quinone and tricyclic systems of mansonone F are essential for anti-MRSA activities.
View Article and Find Full Text PDF