Effects of Supplementation on the Immune System: A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial.

Objective: The purpose of this study was to determine if extract (PTE) has immune-enhancing effects and is safe in healthy adults.

Methods: Subjects who met the inclusion criteria (3 × 10 ≤ peripheral blood leukocyte level ≥ 8 × 10 cells/µL) were recruited for this study. Enrolled subjects ( = 120) were randomly assigned to either the PTE group ( = 60) and were given 2.

Supplementation with extract of Gynostemma pentaphyllum leaves reduces anxiety in healthy subjects with chronic psychological stress: A randomized, double-blind, placebo-controlled clinical trial.

Background: The ethanol extract of Gynostemma pentaphyllum Makino leaves (EGP) has been reported recently to have anxiolytic effects on chronically stressed mice models.

Purpose: We aimed to investigate the efficacy and safety of EGP on anxiety level in healthy Korean subjects under chronic stressful conditions.

Study Design: Double-blind, placebo-controlled trial.