Publications by authors named "Soon-Jun Hong"
Article Synopsis
- High-intensity statin therapy is effective in reducing mortality and cardiovascular events in patients with atherosclerotic cardiovascular disease (ASCVD), but elderly patients often tolerate moderate-intensity statins better due to intolerance risks.
- A study compared the incidence of statin-associated muscle symptoms (SAMS) and low-density lipoprotein cholesterol (LDL-C) levels in elderly ASCVD patients on either high-intensity statins or moderate-intensity statins combined with ezetimibe.
- Results showed that combination therapy significantly reduced SAMS (0.7% vs 5.7%) while achieving comparable LDL-C target levels (75.4% vs 68.7%), indicating that moderate-intensity therapy with ezetim
Background And Objectives: The risk profiles, procedural characteristics, and clinical outcomes for women undergoing bifurcation percutaneous coronary intervention (PCI) are not well defined compared to those in men.
Methods: COronary BIfurcation Stenting III (COBIS III) is a multicenter, real-world registry of 2,648 patients with bifurcation lesions treated with second-generation drug-eluting stents. We compared the angiographic and procedural characteristics and clinical outcomes based on sex.
Background: Lercanidipine, a newer-generation calcium channel blocker, is recognized for its effective antihypertensive properties and reduced side effects. This study aims to compare the effectiveness of lercanidipine and amlodipine in preventing major adverse cardiovascular events (MACE) in hypertensive patients.
Methods: A multicenter, retrospective observational study was conducted using the electronic medical records database from three tertiary hospitals in South Korea between 2017 and 2021.
Importance: In patients with atherosclerotic cardiovascular disease (ASCVD), intensive lowering of low-density lipoprotein (LDL) cholesterol levels with high-intensity statins is generally recommended. However, alternative approaches considering statin-related adverse effects and intolerance are needed.
Objective: To compare the long-term efficacy and safety of an alternative LDL cholesterol-lowering strategy vs high-intensity statin strategy in patients with ASCVD in randomized clinical trials.
Article Synopsis
- * Using this imaging technology, doctors can perform better heart surgeries called PCI, especially for complicated cases and high-risk patients.
- * The paper reviews the latest research and guidelines on how to use this imaging to improve heart stent placement and overall patient care.
Optical coherence tomography-guided versus angiography-guided percutaneous coronary intervention for patients with complex lesions (OCCUPI): an investigator-initiated, multicentre, randomised, open-label, superiority trial in South Korea.
Lancet
September 2024
Article Synopsis
- The OCCUPI trial aimed to determine if optical coherence tomography (OCT) guidance during percutaneous coronary intervention (PCI) provides better clinical outcomes compared to traditional angiography guidance for complex heart lesions over a year.
- Conducted across 20 hospitals in South Korea, the trial included 1,604 patients aged 19-85 and utilized randomization to assign participants to either OCT or angiography guidance during their PCI procedure.
- The main outcome measured was the rate of major adverse cardiac events, but the effectiveness of OCT guidance in reducing these events compared to angiography guidance remains uncertain, as the study was designed to assess potential clinical benefits.
Article Synopsis
- The study examined the effects of proton pump inhibitors (PPIs) on patients who underwent percutaneous coronary intervention (PCI) while taking clopidogrel for antiplatelet therapy, particularly focusing on their clinical outcomes and PRU levels.
- Among 13,160 patients, those using PPIs had higher PRU levels but did not show a significant increase in serious cardiovascular events when compared to non-users, with primary outcomes occurring in a similar proportion.
- However, for patients carrying certain genetic variations (CYP2C19 loss-of-function alleles), PPI use was associated with an increased risk of adverse outcomes, highlighting complex interactions between medication and genetics.
Article Synopsis
- The study investigated the impact of strict blood pressure (BP) control on health outcomes in patients with diabetic kidney disease (DKD), focusing on whether targeting systolic BP (SBP) below 130 mmHg has benefits compared to below 140 mmHg.
- A total of 341 DKD patients were split into standard and strict BP control groups, with cardiovascular and renal events being monitored over a follow-up period of 2.8 years.
- Results showed that while strict BP control didn't significantly lower the risk of health events, maintaining achieved SBP levels between 130-139 mmHg was linked to a reduced risk of cardiovascular and renal complications.
Background And Objectives: Lipid lowering therapy is essential to reduce the risk of major cardiovascular events; however, limited evidence exists regarding the use of statin with ezetimibe as primary prevention strategy for middle-aged adults. We aimed to investigate the impact of single pill combination therapy on clinical outcomes in relatively healthy middle-aged patients when compared with statin monotherapy.
Methods: Using the Korean National Health Insurance Service database, a propensity score match analysis was performed for baseline characteristics of 92,156 patients categorized into combination therapy (n=46,078) and statin monotherapy (n=46,078) groups.
Background: Carriers of loss-of-function alleles have increased adverse events after percutaneous coronary intervention, but limited data are available for older patients. We aimed to evaluate the prognostic impact of genotypes on clinical outcomes in older patients after percutaneous coronary intervention.
Methods And Results: The study included 1201 older patients (aged ≥75 years) who underwent percutaneous coronary intervention and received clopidogrel-based dual antiplatelet therapy in South Korea.
Background: Although age and body mass index (BMI) significantly affect platelet reactivity units and clinical outcomes after percutaneous coronary intervention, there are limited data on the relationship between high on-treatment platelet reactivity (HPR) and clinical outcomes on age and BMI differences. Thus, we investigated the association of HPR with clinical outcomes according to age and BMI.
Methods And Results: The study analyzed 11 714 patients who underwent platelet function tests after percutaneous coronary intervention.
Background: Despite advancements in coronary artery disease (CAD) treatment with drug-eluting stent, its morbidity and mortality remain high. In context, intravascular imaging-guided percutaneous coronary intervention (PCI) is increasingly recommended for better clinical outcomes in patient with CAD. Near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS), as one of the intravascular imaging methods, is effective in detecting lipid-rich plaques, which is crucial for identifying high-risk or vulnerable plaques employing near-infrared light.
View Article and Find Full Text PDFImportance: Although intravascular ultrasonography (IVUS) guidance promotes favorable outcomes after percutaneous coronary intervention (PCI), many catheterization laboratories worldwide lack access.
Objective: To investigate whether systematic implementation of quantitative coronary angiography (QCA) to assist angiography-guided PCI could be an alternative strategy to IVUS guidance during stent implantation.
Design, Setting, And Participants: This randomized, open-label, noninferiority clinical trial enrolled adults (aged ≥18 years) with chronic or acute coronary syndrome and angiographically confirmed native coronary artery stenosis requiring PCI.
Background: Clinical outcome of ischemic cardiogenic shock (CS) requiring extracorporeal membrane oxygenation is highly variable, necessitating appropriate assessment of prognosis. However, a systemic predictive model estimating the mortality of refractory ischemic CS is lacking. The PRECISE (Prediction of In-Hospital Mortality for Patients With Refractory Ischemic Cardiogenic Shock Requiring Veno-Arterial Extracorporeal Membrane Oxygenation Support) score was developed to predict the prognosis of refractory ischemic CS due to acute myocardial infarction.
View Article and Find Full Text PDFThis study aimed to compare and evaluate the efficacy of the blood pressure (BP) control and cholesterol-lowering effects and safety of combination therapy with telmisartan, rosuvastatin, and ezetimibe versus rosuvastatin and ezetimibe double therapy or telmisartan single therapy in dyslipidemia patients with hypertension. After a wash-out/therapeutic lifestyle change period of ≥4 weeks, a total of 100 eligible patients were randomized and received one of three treatments for 8 weeks: (1) telmisartan 80 mg/rosuvastatin 20 mg/ezetimibe 10 mg (TRE), (2) rosuvastatin 20 mg/ezetimibe 10 mg (RE), or (3) telmisartan 80 mg (T). The primary endpoint was the efficacy evaluation of TRE by comparing changes in mean sitting systolic blood pressure (msSBP) and mean percentage change in low-density lipoprotein-C (LDL-C) from baseline after 8 weeks of treatment.
View Article and Find Full Text PDFArticle Synopsis
- - Stent thrombosis (ST) is a serious complication after coronary artery procedures, and the link between P2Y12 reaction unit (PRU) levels and ST is still not fully understood.
- - Analysis of 11,714 patients from the PTRG-DES registry found that higher PRU and aspirin reaction unit levels are independent predictors of early stent thrombosis (EST), which occurred in 51 patients.
- - The risk of major cardiovascular events within a year was significantly greater for those who had EST (38.2%) compared to those who did not (3.9%), highlighting the importance of monitoring platelet activity after drug-eluting stent procedures.
Article Synopsis
- A study compared the effectiveness and safety of low-intensity atorvastatin combined with ezetimibe against moderate-intensity atorvastatin alone in 290 patients in Korea needing cholesterol-lowering therapy.
- The results showed that the combination therapy (atorvastatin 5 mg + ezetimibe 10 mg) significantly lowered LDL cholesterol levels (49.2% reduction) compared to the other treatment groups, particularly outperforming ezetimibe alone (18.7%).
- Overall, the combination therapy not only improved LDL cholesterol but also led to better results in total cholesterol and triglyceride levels, indicating it's a more effective option for patients with low to intermediate cardiovascular risk.
We aimed to evaluate sex differences in the effects of moderate-intensity statin with ezetimibe combination therapy (rosuvastatin 10 mg plus ezetimibe) versus high-intensity statin (rosuvastatin 20 mg) monotherapy in patients with atherosclerotic cardiovascular disease (ASCVD). This was a sex-specific subgroup analysis of the RACING trial that evaluated the interaction between sex and treatment strategies for the primary outcome (composite of cardiovascular death, major cardiovascular events, or nonfatal stroke at 3 years). Of 3780 patients in the RACING trial, 954 (25.
View Article and Find Full Text PDFBackground: Optical coherence tomography (OCT) and intravascular ultrasound (IVUS) have shown comparable outcomes in guiding percutaneous coronary intervention (PCI). However, their comparative effectiveness in complex coronary artery lesions remains unclear.
Objectives: This study compared the effectiveness and safety of OCT-guided vs IVUS-guided PCI for complex coronary artery lesions.
Limited knowledge exists regarding the predictors of mortality after successful weaning of venoarterial extracorporeal membrane oxygenation (ECMO). We aimed to identify predictors of in-hospital mortality in patients with cardiogenic shock (CS) after successful weaning from ECMO. Data were obtained from a multicenter registry of CS.
View Article and Find Full Text PDFAsian perspective on the recently published practice guideline for acute coronary syndrome by ESC.
Eur Heart J Acute Cardiovasc Care
February 2024
Background: It is still unclear the impact of diabetes mellitus (DM) in complex coronary lesions treated with percutaneous coronary intervention (PCI) which themselves are at increased incidence of adverse events.
Methods: BIFURCAT registry encompassed patients treated with PCI for coronary bifurcation lesion from the COBIS III and the RAIN registry. The primary endpoint was the occurrence of major cardiovascular adverse event (MACE), a composite and mutual exclusive of all-cause death or myocardial infarction (MI) or target-lesion revascularization (TLR).
Background: Intravascular imaging-guided percutaneous coronary intervention (PCI) with intravascular ultrasound (IVUS) or optical coherence tomography (OCT) showed superior clinical outcomes compared with angiography-guided PCI. However, the comparative effectiveness of OCT-guided and IVUS-guided PCI regarding clinical outcomes is unknown.
Methods: In this prospective, multicenter, open-label, pragmatic trial, we randomly assigned 2008 patients with significant coronary artery lesions undergoing PCI in a 1:1 ratio to undergo either an OCT-guided or IVUS-guided PCI.
Article Synopsis
- * In a trial with 374 hypertensive patients, those receiving the triple therapy saw a significant decrease in mean sitting systolic blood pressure after 8 weeks compared to the dual therapy group.
- * Results indicated that the triple therapy led to higher rates of achieving target blood pressure and a lower occurrence of adverse events, especially among women and patients aged 65 and older.