Comprehensive genetic exploration of skeletal dysplasia using targeted exome sequencing.

Purpose: The purpose of this study was to evaluate the clinical utility of targeted exome sequencing (TES) as a molecular diagnostic tool for patients with skeletal dysplasia.

Methods: A total of 185 patients either diagnosed with or suspected to have skeletal dysplasia were recruited over a period of 3 years. TES was performed for 255 genes associated with the pathogenesis of skeletal dysplasia, and candidate variants were selected using a bioinformatics analysis.

Prognostic factors of septic arthritis of hip in infants and neonates: minimum 5-year follow-up.

Background: The authors conducted the present study to identify clinical and radiological prognostic factors in infants and neonates with septic arthritis of the hip.

Methods: The authors retrospectively reviewed the records of 31 patients with septic arthritis of the hip. All of the patients were younger than 18 months old.

Repairing the annular ligament is not necessary in the operation of Mason type 2, 3 isolated radial head fractures if the lateral collateral ligament is intact: Minimum 5 years follow-up.

Introduction: The repair of annular ligament after open reduction and internal fixation of radial head fracture could produce the irritation or crepitation during range of motion exercise. The purpose of this study is to evaluate the significance of unrepaired annular ligament during fixation of isolated radial head fractures.

Materials And Methods: Retrospectively we reviewed the twenty-five patients who underwent surgical fixation with a plate for Mason type 2, 3 isolated radial head fracture without annular ligament repair.

Percutaneous retrograde intramedullary single wire fixation for metacarpal shaft fracture of the little finger.

This study aimed to evaluate the anatomic and functional outcome of retrograde intramedullary single wire fixation for metacarpal shaft fractures of the little finger. Forty consecutive patients with closed metacarpal shaft fractures of the little finger who have been treated with retrograde intramedullary single wire fixation were evaluated. Fracture union and angulation were analyzed radiologically, and clinical evaluations were performed including the percentage of total active motion (%TAM), disabilities of the arm, shoulder and hand (DASH) score, and complications.

Percutaneous transphyseal pin fixation through the distal physis of the ulna in pediatric distal fractures of the forearm.

Objective: The purpose of this study is to report the long-term results of transphyseal Kirschner (K) wire fixation through the distal physis of ulna in distal fractures of forearm in pediatrics and to determine the safety of this procedure.

Design: We performed the study retrospectively.

Setting: All of the patient was treated operatively in the level 2 trauma center.

Effects of corticosteroid on the expressions of neuropeptide and cytokine mRNA and on tenocyte viability in lateral epicondylitis.

Background: The purpose of this study was to determine the reaction mechanism of corticosteroid by analyzing the expression patterns of neuropeptides (substance P (SP), calcitonin gene related peptide (CGRP)) and of cytokines (interleukin (IL)-1α, tumor growth factor (TGF)-β) after corticosteroid treatment in lateral epicondylitis. In addition, we also investigated whether corticosteroid influenced tenocyte viability.

Methods: The corticosteroid triamcinolone acetonide (TAA) was applied to cultured tenocytes of lateral epicondylitis, and the changes in the mRNA expressions of neuropeptides and cytokines and tenocyte viabilities were analyzed at seven time points.

Remodeling after lateral closing-wedge osteotomy in children with cubitus varus.

The purpose of this study was to evaluate the effectiveness of supracondylar lateral closing-wedge osteotomy of the humerus in children and the postoperative remodeling of the lateral condylar prominence. Lateral closing-wedge osteotomy for cubitus varus deformity was performed in 52 children. In all cases, medial translation for decreasing lateral condylar prominence or transposition of the ulnar nerve was not performed.

Anterior debridement and strut graft with pedicle screw fixation for pyogenic spondylitis.

Study Design: A retrospective study.

Purpose: We evaluated the results of the use of anterior debridement and interbody fusion followed by posterior spinal instrumentation.

Overview Of Literature: An early diagnosis of pyogenic spondylitis is difficult to obtain.

Effects of repeated administration of Uncaria hooks on the acquisition and central neuronal activities in ethanol-treated mice.

The effects of the repeated administration of Uncaria hooks were examined on the impaired memory acquisition and the level of neurotransmitters in the cortex, hippocampus and striatum in ethanol-treated mice, in comparison with those with L-deprenyl and N-methyl-D-glucamine as positive controls. Ethanol-induced amnesia was significantly ameliorated by repeated administration of methanol extract and alkaloid fraction of Uncaria hooks, similar to in the positive controls. Treatment with methanol extract and alkaloid fraction of Uncaria hooks significantly reduced the ethanol-induced increase of dopamine in the hippocampus.