Matrix metalloproteinases and tissue inhibitors of metalloproteinases in the aqueous humour of patients with primary angle closure glaucoma - a quantitative study.

Background: Altered levels of specific matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in the aqueous humour of primary open-angle glaucoma (POAG) eyes have been described. In this study, levels of specific MMPs and TIMPs in the aqueous humour of primary angle-closure glaucoma (PACG) eyes were measured and compared with those of POAG as well as non-glaucoma control eyes.

Methods: Aqueous humour from 16 PACG, 28 POAG and 27 control eyes were sampled during intraocular surgery.

Assessment of polymerase chain reaction in the detection of pseudomonas aeruginosa in contact lens-induced severe infectious keratitis.

Purpose: The aim of this study is to evaluate the role of real-time polymerase chain reaction (PCR) and conventional bacterial culture methods in the detection of Pseudomonas aeruginosa in contact lens-induced severe, partially treated corneal ulcers referred to a tertiary center.

Methods: The study duration was 6 months. All patients with contact lens-related corneal ulcer, requiring admission during the study period were recruited.

Clinical and radiologic outcome of total hip arthroplasty performed by trainee compared with consultant orthopedic surgeons.

Data were prospectively collected on 139 total hip arthroplasties (THAs) performed by supervised specialist registrars (residents) and 397 THAs performed by consultants. The Harris Hip Score and data on comorbidity, blood loss, transfusion requirements, re-operation, dislocation, and death were recorded. Radiologic assessment of acetabular and femoral component alignment and cementation was made using 114 trainee radiographs that were available for review at 6 months.