Clinical Characteristics and Comparison of Different Prognostic Scores in Wilson's Disease.

Aim: Wilson's disease (WD) is a rare autosomal recessive disease, that can involve any organ of the body, the main ones being the liver and the brain. These patients can have varied presentations, ranging from having no symptoms to having neurological manifestations to features of chronic liver disease (CLD). Those patients that end up having CLD are prognosticated the Child-Turcotte-Pugh (CTP) score and the Model for End-stage Liver Disease (MELD) score.

Frequency, Risk Factors, and Outcome of Definite Stent Thrombosis: A Single-Center Experience.

Introduction Stent thrombosis (ST) is a serious and potentially life-threatening complication of primary or complex high-risk percutaneous coronary intervention (PCI). Multiple factors are said to precipitate ST, related to the patient's clinical comorbidities, lesion characteristics, operative technique, and post-procedural care. The older-generation stents were thought to be involved in early ST.

Efficient removal of refractory organics in landfill leachate concentrates by electrocoagulation in tandem with simultaneous electro-oxidation and in-situ peroxone.

Leachate concentrates, an effluent produced from nanofiltration and/or reverse osmosis, contains a high amount of salts and dissolved organics especially refractory organics. Thus, the treatment of leachate concentrates would consume high energy or a large amount of chemicals. The present study is to develop an effective treatment method by using coupled electrochemical methods with the least possible energy consumption.

Enhanced electro-oxidation/peroxone (in situ) process with a Ti-based nickel-antimony doped tin oxide anode for phenol degradation.

Recently, a novel proof-of-concept oxygen reduction reaction (ORR) based electro-oxidation (EO) process has been developed, which was accomplished by integrating anodic electrochemical oxidation coupled with an in situ electro-peroxone process, by harnessing the anodic by-product O reacted with ORR cathode generated HO. To further enhance EO coupled in situ electro-peroxone, a nickel and antimony doped tin oxide anodic catalyst layer, namely NATO, was fabricated on Ti mesh to improve anodic oxidation and reinforce the generation of O, thus promoting in situ Electro-peroxone. As a result, O generation rate was enhanced by 12.

Intestinal Spirocheteosis in a Patient with Celiac Disease.

A young girl presented to us with recurrent diarrhea along with a history of 5 kg weight loss in one year. On examination, she appeared pale, while her laboratory reports showed a low hemoglobin, mean corpuscular volume (MCV) and serum albumin. Her erythrocyte sedimentation rate (ESR) was slightly raised with her iron profile suggestive of iron deficiency anemia.

Tuberculous Paraspinal Abscess Invading Esophagus: A Rare Cause of Dysphagia.

Esophageal involvement by mycobacterium tuberculosis is a rare entity even in the endemic regions. The common presenting complaint in esophageal tuberculosis are deglutition disorders in which patients primarily present with difficulty in swallowing. The most common site of esophageal involvement is the middle-third at the level of carina.

Zn-doped SiO nanoparticles preparation and characterization under the effect of various solvents: Antibacterial, antifungal and photocatlytic performance evaluation.

The biological profiling (antibacterial and antifungal) and photocatalytic activity (PCA) was evaluated of newly synthesized Zinc-doped SiO nanoparticles (Zn-d-SiO NPs) under the effect of different solvents (n-hexane, acetonitrile, isoamyl alchol). Antibacterial potential against Bacillus subtilis and Escherichia coli, and antifungal activities against Candida parapsilosis and Aspergilus niger were investigated by the Disc diffusion method. The advanced techniques including Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FT-IR), Transmission Electron Microscopy (TEM), X-ray diffraction (XRD), Thermo-gravimeteric Analysis (TGA), Atomic forced microscopy (AFM) and Dynamic Light Scattering (DLS) were used for the characterization of Zn-d-SiO NPs.

Obsessive compulsive disorder in children and adolescents: duration of maintenance drug treatment.

Introduction: Obsessions or compulsions that cause personal distress or social dysfunction have been reported to affect about 3% of children and adolescents. In children, the disorder often presents at around 10 years of age. It persists in about 40% of children and adolescents at mean follow-up of 5.

Clinical presentation and predictors of survival in patients with Budd Chiari syndrome: experience from a tertiary care hospital in Pakistan.

Objective: To determine aetiology, clinical presentation and predictors of survival in Budd Chiari Syndrome patients.

Methods: The prospective observational study based on non-probability convenient sampling was conducted at the Sindh Institute of Urology and Transplantation (SIUT), Karachi, and comprised Budd Chiari Syndrome patients between January 2004 and December 2013. The patients were evaluated for onset of symptoms, causes, mode of presentation and predictors of survival.

Clinical presentation of extrahepatic portal vein obstruction: 10-year experience at a tertiary care hospital in Pakistan.

Objective: To evaluate the clinical presentation, possible etiological factors, management and outcome of patients in our hospital with extrahepatic portal vein obstruction (EHPVO).

Materials And Methods: This study included patients with EHPVO followed up in our department during last 10 years. Patients of cirrhosis with EHPVO were excluded.

Clinical presentation of hepatitis D in Pakistani children.

Background: There are limited data on hepatitis D in children. The aim of this study was to assess the clinical presentation of hepatitis D virus (HDV) infection in Pakistani children.

Materials And Methods: All pediatric patients (age≤18 years) seen in the clinic with chronic HDV infection and detectable HDV RNA (n=48) were compared with consecutive hepatitis B virus (HBV) monoinfection patients (n=48).

Clinical Profile and HLA Typing of Autoimmune Hepatitis From Pakistan.

Background: Human leukocyte antigen (HLA) typing in autoimmune hepatitis (AIH) has been investigated in different populations and ethnic groups, but no such data is available from Pakistan.

Objectives: The aim of this study was to evaluate the clinical profile of autoimmune hepatitis (AIH), and determine the associated antigens and alleles by performing HLA typing.

Patients And Methods: A total of 58 patients, diagnosed and treated as AIH in the last 10 years were reviewed.

Obsessive compulsive disorder.

Introduction: Obsessions or compulsions that cause personal distress or social dysfunction affect about 1% of adult men and 1.5% of adult women. About half of adults with obsessive compulsive disorder (OCD) have an episodic course, whereas the other half have continuous problems.

Is there any association of extra hepatic biliary atresia with cytomegalovirus or other infections?

The objective of this study was to find any association of extrahepatic biliary atresia (EHBA) with a possible infectious etiology. Infants diagnosed to have EHBA were tested by blood PCR for cytomegalovirus (CMV), Ebstein-Barr virus, HBsAg, anti-HCV and IgM antibodies for CMV, toxoplasma, rubella, and herpes infections. Thirty-three infants of EHBA were included in the study, male 22, median age when diagnosed 2.

Selective serotonin re-uptake inhibitors (SSRIs) versus placebo for obsessive compulsive disorder (OCD).

Background: Obsessive compulsive disorder is a common and disabling disorder. A significant proportion of patients manifest a chronic course. Individual randomised controlled trials (RCTs) have shown that selective serotonin re-uptake inhibitors (SSRIs) are effective in this condition.

Obsessive compulsive disorder.

Introduction: Obsessions or compulsions that cause personal distress or social dysfunction affect about 1% of men and 2% of women. About half of people with obsessive compulsive disorder (OCD) have an episodic course, whereas the other half have continuous problems. Up to half of people show improvement of symptoms over time.

Progressive familial intrahepatic cholestasis.

Progressive familial intrahepatic cholestasis (PFIC) is an important cause of cholestatic liver disease and biliary cirrhosis in pediatric population. Three cases of PFIC are described that were diagnosed on the basis of family history, pruritus, cirrhosis and / or paucity of interlobular bile ducts on liver biopsy and presence of extrahepatic biliary tree on imaging. These patients were initially labeled as suffering from extra-hepatic biliary atresia and neonatal hepatitis.

Biliary atresia with situs inversus: an experience shared.

Biliary Atresia (BA) is a well-known entity and can present with multiple congenital anomalies. BA is one of the most common conditions in which pediatric liver transplant is performed. Identification of Biliary atresia with situs inversus (SI) has not been documented in Pakistan.

Assessing observational studies of medical treatments.

Background: Previous studies have assessed the validity of the observational study design by comparing results of studies using this design to results from randomized controlled trials. The present study examined design features of observational studies that could have influenced these comparisons.

Methods: To find at least 4 observational studies that evaluated the same treatment, we reviewed meta-analyses comparing observational studies and randomized controlled trials for the assessment of medical treatments.