Publications by authors named "Sookyung Seo"
Article Synopsis
- The Golgi apparatus is crucial for transporting macromolecules in cells, but its role in lipid transport is not well understood.
- Researchers found that removing the protein GRASP55 from mice decreases body fat and makes them resistant to gaining weight on a high-fat diet, due to impaired fat absorption in the intestines.
- GRASP55 is essential for targeting specific lipases involved in the formation and secretion of chylomicrons, and its deficiency leads to abnormal lipid droplet formation, indicating the significance of the Golgi in lipid regulation and potential obesity treatments.
Background: Regular reformulation of currently available vaccines is necessary due to the unpredictable variability of influenza viruses. Therefore, vaccine based on a highly conserved antigen with capability of induction of effective immune responses could be a potential solution. Influenza matrix protein-2 (M2) is highly conserved across influenza subtypes and a promising candidate for a broadly protective influenza vaccine.
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