Evaluation of compounded trilostane packets for dogs with naturally occurring hyperadrenocorticism.

Background: Dogs treated for naturally occurring hyperadrenocorticism (NOH) in Korea often appear to require higher doses of trilostane than recommended by authors in the United States, Europe, or the United Kingdom. This phenomenon may be related to compounding trilostane into packets, which is a common practice among veterinary clinics in Korea.

Objective: Analyze packets filled by hand and others filled using a semi-automatic packing device for accuracy of trilostane strength.

Activity-dependent dynamic microtubule invasion of dendritic spines.

Dendritic spines are the primary sites of contact with presynaptic axons on excitatory hippocampal and cortical neurons. During development and plasticity spines undergo marked changes in structure that directly affect the functional communication between neurons. Elucidating the cytoskeletal events that induce these structural changes is fundamental to understanding synaptic biology.