Temporal Dynamics of Serum Perforin and Granzymes in Three Different Clinical Stages of Virus-Induced Severe Fever with Thrombocytopenia Syndrome.

Virus-induced severe fever with thrombocytopenia syndrome (SFTS) induces a cell-mediated immune response that likely contributes to virus control in SFTS patients. To identify the temporal changes of the cell-mediated immune response, we investigated the changes in serum levels of perforin and granzymes at early periods after illness onset in SFTS patients. We analyzed 32 SFTS patients and compared the temporal patterns of serum perforin and granzyme A and B to that of 20 healthy control adults using the Mann-Whitney U test.

Impact of travel restrictions for travellers from China on the internal spread of SARS-CoV-2 in South Korea.

South Korea implemented restrictions on travel from China in January of 2023. In this scenario-based model, we estimated that the travel restrictions for inbound travellers from China were associated with a 0.3–9.