Azumamides A-E: Isolation, Synthesis, Biological Activity, and Structure-Activity Relationship.

Cyclic peptides are one of the important chemical groups in the HDAC inhibitor family. Following the success of romidepsin in the clinic, naturally occurring cyclic peptides with a hydrophilic moiety have been intensively studied to test their function as HDAC inhibitors. Azumamides A-E, isolated from , are one of the powerful HDAC inhibitor classes.