Aberrant ERK signaling in astrocytes impairs learning and memory in RASopathy-associated BRAF mutant mouse models.

RAS/MAPK pathway mutations often induce RASopathies with overlapping features, such as craniofacial dysmorphology, cardiovascular defects, dermatologic abnormalities, and intellectual disabilities. Although BRAF gene mutations are associated with cardio-facio-cutaneous (CFC) syndrome and Noonan syndrome, it remains unclear how these mutations impair cognition. Here, we investigated the underlying neural mechanisms using several mouse models harboring a gain-of-function BRAF mutation (K499E) discovered in RASopathy patients.

Nonsurgical Correction of Deviated Nose Using Hyaluronic Acid Fillers.

Background: Nonsurgical correction of a deviated nose using hyaluronic acid (HA) fillers offers a minimally invasive alternative to traditional rhinoplasty. This study presents a series of cases demonstrating the efficacy of HA fillers in achieving improved nasal symmetry and alignment.

Methods: Five female patients, aged 23 to 44, with varying degrees of nasal deviation, were treated with HA fillers.

Injectable Hyaluronic Acid Filler for Increasing Head Circumference and Contouring Cephalic Flatness: An Innovative Approach.

Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors   www.springer.

Discovery of the Ligament of Modiolus: Anatomical Insights and Clinical Relevance.

The modiolus is a critical anatomical structure in facial expressions and oral competence, serving as a hub where multiple muscles converge. Our recent cadaveric study has identified a previously unreported structure, the ligament of modiolus, aligning with the line of ligament between the modiolus and its adjacent muscular and fascial attachments. This novel finding offers new perspectives on the anatomical organisation of the perioral region and its functional significance.

sp. nov., Isolated from the Marine Sponge, , and Reclassification of as comb. nov.

A Gram-stain-negative, facultative anaerobic rods, designated as strain 219JJ12-13, was isolated from a marine sponge, , in Jeju-do, Republic of Korea. The cells displayed catalase and oxidase activity and were non-motile. Strain 219JJ12-13 grew at 10-37°C (optimum, 25-30°C), pH 6.

Why Does an "Avatar Nose" Appear After Dermal Filler Injection? Insights From a Cadaveric Study on the Nasofrontal Ligament.

Background: Nonsurgical rhinoplasty (NSR) with dermal fillers has gained popularity because of its immediate and visible results, minimal downtime, and long-lasting effects. However, complications such as filler migration can lead to the development of the "Avatar nose," a condition where the nose appears unnaturally wide and bulbous in the nasion area, disrupting facial harmony. This phenomenon is often exacerbated by the presence of a taut nasofrontal ligament, which tethers the periosteum to the dermal layer and influences nasal contour.

Facial Thread Lifting Complications: Underlying Causes.

Introduction: Thread lifting procedures are becoming increasingly popular for facial rejuvenation. However, various complications can arise during these procedures, many of which are influenced by anatomic factors.

Methods: In this section, the authors explore the potential side effects associated with thread lifting and emphasize the anatomic structures that require careful attention.

Injection Techniques for Filler Procedures With Illustration: Narrative Review.

This narrative review explores the various injection techniques utilized in facial filler procedures, emphasizing their applications, benefits, and potential complications. The increasing demand for total facial contouring and rejuvenation has led to a rise in the use of volumizing fillers and the integration of these procedures with other treatments such as toxins, threads, lasers, radiofrequency, and ultrasound. Achieving satisfactory results necessitates a comprehensive understanding of facial anatomy and the effects of aging on skin tissue.

Cerebellar Bergmann glia integrate noxious information and modulate nocifensive behaviors.

The cerebellum is activated by noxious stimuli and pathological pain but its role in noxious information processing remains unknown. Here, we show that in mice, cutaneous noxious electrical stimuli induced noradrenaline (NA) release from locus coeruleus (LC) terminals in the cerebellar cortex. Bergmann glia (BG) accumulated these LC-NA signals by increasing intracellular calcium in an integrative manner ('flares').

Anatomy-based Filler Injection: Diagnosis to Treatment Techniques for the Glabellar Region.

Glabellar filler injections are a popular non-surgical approach to address depressions and wrinkles caused by aging, muscle activity, and soft tissue loss. An anatomy-based technique emphasizes understanding the complex structure of the glabellar region, including the corrugator supercilii and procerus muscles, and the superficial vascular pathways, such as the supratrochlear and supraorbital arteries. Effective treatment involves precise filler placement, often combined with botulinum toxin to address both volume loss and dynamic wrinkles.

Anatomical etiology of bunny lines based on cadaveric dissection and ultrasonographic evaluation.

Bunny lines are vertical and diagonal wrinkles attributed to contractions of the nasalis muscle. Common management involves botulinum toxin (BoNT) injections into wrinkles immediately below the nasal bridge. Here, we investigated the anatomical structures underneath bunny lines and their relationships with adjacent muscular structures.

Vertex Augmentation With Hyaluronic Acid Filler: A Novel Technique for Height Enhancement and Cephalic Contouring.

Height augmentation and cephalic contouring using hyaluronic acid (HA) fillers represent an innovative approach in minimally invasive aesthetic medicine. This study introduces a novel technique for vertex augmentation, leveraging cross-linked HA fillers to achieve subtle height enhancement and cephalic contouring. A 42-year-old male patient seeking non-surgical height augmentation underwent vertex injections with 15 ml of HA filler (e.

Non-invasive procedure implementation for enhanced smile facial muscle movement after orthognathic surgery: a case report.

This study examined the case of 27-year-old female who underwent orthognathic surgery to correct class 3 malocclusion, resulting in an unnatural smile. The research aimed to assess the efficacy of non-invasive treatment in enhancing facial muscle movement during smiling to achieve a natural smile. The patient received eight sessions of treatment using non-invasive devices, and facial assessment were conducted using three-dimensional scanner (Morpheus 3D Scanner) to evaluate facial features in both relaxed and maximum smile states pre- and post-treatment.

sp. nov., isolated from the marine sponge, .

A facultative anaerobic Gram-negative bacterium, designated as strain 2205BS29-5, was isolated from a marine sponge, , in Beomseom on Jeju Island, Republic of Korea, and taxonomically characterized. The cells were catalase and oxidase positive, non-motile, coccoid-rod shaped and capable of poly-β-hydroxybutyrate production. Growth was observed at 10-37 °C (optimum, 25 °C) and pH 5.

Ultrasonographic study and anatomical guidelines for botulinum neurotoxin injection into the parotid gland.

Benign enlargement of the parotid gland hypertrophy results in a bulky lateral facial contour and esthetic appearance. This study aimed to determine the depth from the skin surface to the parotid fascia, which encompasses the parotid gland. The anatomical properties of the parotid glands were evaluated in 40 patients using ultrasonography.

Anatomical Considerations for Thread Lifting Procedure.

Background: Thread lifting is a minimally invasive procedure that enhances facial aesthetics by repositioning sagging tissues with absorbable threads. It requires a comprehensive understanding of facial anatomy for safe and effective results.

Aims: This study aims to highlight the critical anatomical considerations in thread lifting, including the navigation of facial vascular structures, the protection of facial nerves, manipulation of fat compartments, and engagement of retaining ligaments.

Ultrasonographic assessment of the lateral pterygoid muscle for BoNT-A injection.

The upper head of the lateral pterygoid muscle (LPM) is known to insert into the capsule of the temporomandibular joint and articular disc, and therefore its relationship with temporomandibular disorders (TMD) has been consistently suggested. The aim of the study was to determine the anatomical features of the LPM using ultrasonographic (US) imaging. Around 120 hemifaces from 60 healthy Korean volunteers were included in this study.

Anatomical Guidelines and Technical Tips for Neck Aesthetics with Botulinum Toxin.

Botulinum toxin can be used for various purposes to enhance neck aesthetics, addressing concerns such as platysmal bands, optimizing the cervicomental angle, preventing worsening of horizontal neckline and decolletage lines during aging, submandibular gland hypertrophy, and hypertrophied superior trapezius muscle. Understanding the anatomy of muscles such as the trapezius, platysma, and submandibular gland is crucial for achieving desirable outcomes with botulinum toxin administration. Techniques for injecting botulinum toxin into these muscles are discussed, emphasizing safety and efficacy.

Poly-d,l-Lactic Acid Via Transdermal Microjet Drug Delivery for Treating Rosacea in Asian Patients.

Background: Rosacea, a chronic inflammatory skin condition, is marked by enduring redness, visible blood vessels, and inflammatory eruptions in facial areas. Managing rosacea remains a persistent challenge for dermatologists, especially in cases unresponsive to conventional treatments. Injectable poly-d,l-lactic acid (PDLLA) has shown promise in treating erythema and telangiectasia associated with rosacea in addition to age-related concerns.

Exploring novel AAR antagonists: Design, synthesis, and evaluation of 2,6,9-trisubstituted purine derivatives as promising antifibrotic agents.

A series of 2,6,9-trisubstituted purine derivatives were designed and synthesized with diverse chemical moieties. Through a comprehensive biological evaluation, we identified 4-(6-(methylamino)-2-(phenylethynyl)-9H-purin-9-yl)phenol (6a) as a promising AAR antagonist with potent antifibrotic properties. Compound 6a demonstrated significant efficacy in inhibiting CRE promoter activity and in reducing the expression of fibrogenic marker proteins and downstream effectors of AAR activation, surpassing the AAR antagonist ZM241385 and initial screening hits, 9-benzyl-N-methyl-2-(phenylethynyl)-9H-purin-6-amine (5a) and 9-((benzyloxy)methyl)-N-methyl-2-(phenylethynyl)-9H-purin-6-amine (5j).

Reverse and antegrade vector thread lifting techniques: Correcting nasolabial and marionette lines.

Background: This study evaluates the efficacy of reverse and antegrade thread lifting vectors in conjunction with thread selection for correcting nasolabial folds and marionette lines, aiming to enhance treatment precision and effectiveness.

Methods: Three female patients aged 43, 48, and 53, presenting with primary concerns regarding nasolabial folds, underwent distinct treatment regimens utilizing various types of threads and vectors. Additionally, video demonstrations were recorded to showcase the procedural techniques employed in each case.