Therapeutic Potential of Extract for Hair Health Enhancement: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Hair health critically influences both aesthetic appearance and psychological well-being. Existing treatments often show limited efficacy and may cause side effects. (GP), known for its antioxidant and anti-inflammatory properties, has emerged as a promising botanical agent, although clinical evidence regarding its hair health benefits remains limited.

Potential Chondroprotective Effect of L. Water Extract on SW1353 Cell.

Inflammation plays a critical role in the pathogenesis of osteoarthritis (OA). The objective of this study was to investigate the anti-inflammatory and chondroprotective properties of L. water extract (AWE) following the induction of inflammation in cartilage cells (SW1353 cell) through the administration of interleukin-1 beta (IL-1β).

Feasibility Study of Single-Port Laparoscopic Techniques for Pancreatic Exploration, Ultrasound, and Biopsy in Dogs.

This study aimed to evaluate the feasibility of single-port laparoscopic pancreatic exploration, laparoscopic ultrasonography, and pancreatic biopsy in dogs. Six clinically healthy Beagles (median age: 13 months; range: 12-30 months; median weight: 8.81 kg; range: 7.

Mutant KRAS and GATA6 Stratify Survival in Patients Treated with Chemotherapy for Pancreatic Adenocarcinoma: A Prospective Cohort Study.

Background: Several pancreatic adenocarcinoma (PA) biomarkers beyond the traditional carbohydrate antigen (CA)19-9 have been identified but are lacking large-scale prospective validation. This prospective cohort study evaluated the prognostic impact of potential PA biomarkers.

Methods: We enrolled 238 of 288 patients with histologically proven PA.

Construction of Chitosan Oligosaccharide-Coated Nanostructured Lipid Carriers for the Sustained Release of Strontium Ranelate.

Background: Strontium ranelate (SR) is an effective bone regeneration drug; however, its low bioavailability and strong hydrophilicity cause a strong cytotoxicity, venous thrombosis, and allergic reactions when administered in its free form. This study aims to enhance the SR bioavailability by utilizing nanostructured lipid carriers (NLC) as a drug delivery system (DDS).

Methods: To improve the drug delivery efficiency and sustained release of the NLC, their surfaces were coated with chitosan oligosaccharide (COS), a natural polymer.

Beliefs and attitudes of family caregivers of People with dementia toward advance care planning: A Q methodology study.

Family caregivers' perspectives for advance care planning (ACP) are critically important to reflect the end-of-life wishes of people with dementia. Culture can influence ACP practice and people's perspectives toward it. Little is known about family caregivers' perspectives toward ACP in Asian countries, especially in Korea.

Multiprotease supplementation in laying hen diets: Impact on performance, egg quality, digestibility, gut histomorphology, and sustainability.

Laying hen responses to supplemental multiprotease on performance, egg quality, digestibility, gut histomorphology, nitrogen excretion, and economic performance of laying hens until 37 weeks of age were investigated. A total of 189 25-week-old Hy-Line Brown hens were housed in enriched cages (7 birds/cage) and randomly allocated to 1 of 3 diets with 9 replicates per treatment. Dietary treatments included: an adequate positive control- PC [met the breed and age standards for crude protein (CP) and amino acids (AA)]; negative control- NC (90 % CP and AA requirement); and NC supplemented with multiprotease - NCMP.

Sex Differences in Apolipoprotein E and Alzheimer Disease Pathology Across Ancestries.

Importance: Age, sex, and apolipoprotein E (APOE) are the strongest risk factors for late-onset Alzheimer disease (AD). The role of APOE in AD varies with sex and ancestry. While the association of APOE with AD biomarkers also varies across sex and ancestry, no study has systematically investigated both sex-specific and ancestry differences of APOE on cerebrospinal fluid (CSF) biomarkers together, resulting in limited insights and generalizability.

Advanced Exosome Isolation through Electrophoretic Oscillation-Assisted Tangent-Flow Ultrafiltration with a PVDF-Fiber-Coated SiN Nanofilter.

This study introduces a comprehensive approach to enhancing SiN nanofilters for exosome isolation from bovine milk using the electrophoretic oscillation-assisted tangent-flow ultrafiltration (EPOTF) process. Reinforcing the nanofilter with electro-spun poly(vinylidene fluoride) (PVDF) fibers significantly improved durability under high-pressure conditions, withstanding nearly 2.8 times greater pressures than nonreinforced nanofilters.

Insights into hepatocellular adenomas in Asia: molecular subtypes, clinical characteristics, imaging features, and hepatocellular carcinoma risks.

Hepatocellular adenomas (HCAs) are benign monoclonal liver tumors. Advances in molecular studies have led to the identification of distinct subtypes of HCA with unique pathways, clinical characteristics, and complication risks, underscoring the need for precise diagnosis and tailored management. Malignant transformation and bleeding remain significant concerns.

Spontaneous bone regeneration achieved through one-step alignment of human mesenchymal stem cell-embedded collagen.

Optimizing cell-matrix interactions for effective bone regeneration remains a significant hurdle in tissue engineering. This study presents a novel approach by developing a hMSC-embedded 3D aligned collagen for enhanced bone regeneration. A one-step mechanical strain was applied to a mixture of hMSCs and collagen, producing an hMSC-embedded, aligned 3D collagen hydrogel patch that mimics the natural bone matrix.

Early clinical remission and its role in lung function decline and exacerbation in adult Korean patients with asthma.

Introduction: Despite advancements in asthma management, many patients continue to experience poor disease control, lung function decline, and frequent exacerbations. Clinical remission (CR) has been proposed as a novel treatment target and surrogate marker for long-term outcomes. This study evaluates whether early CR at 1 year after inhaled corticosteroid (ICS) initiation influences lung function decline and exacerbation risk in asthma.

Deep Learning-based Multi-class Classification for Neonatal Respiratory Diseases on Chest Radiographs in Neonatal Intensive Care Units.

Objective Accurate and timely interpretation of chest radiographs is essential for assessing respiratory distress and guiding clinical management to improve outcomes of critically ill newborns. This study aimed to introduce a deep learning-based automated algorithm designed to classify various neonatal respiratory diseases and healthy lungs using a large dataset of high-quality, multi-class labeled chest X-ray images from neonatal intensive care units (NICUs). Methods Portable supine chest X-ray images for six common conditions (healthy lung, respiratory distress syndrome (RDS), transient tachypnea of the newborn (TTN), air leak syndrome (ALS), atelectasis, and bronchopulmonary dysplasia (BPD)) and demographic variables (gestational age and birth weight) were retrospectively collected from 10 university hospitals in Korea.

Synthesis and Biological Evaluation of Peripheral 5HT Antagonists for Liver Fibrosis.

Liver fibrosis is characterized by an excessive accumulation of extracellular matrix components, leading to the distortion of liver architecture and function. Recent studies have shown that antagonizing 5-hydroxytryptamine receptor 2B (5HT) stimulates the apoptosis of activated hepatic stellate cells and inhibits their proliferation while concurrently regressing hepatocyte proliferation. In this study, we present compound , which demonstrates promising efficacy both and .

Synthesis and Characterizations of a Nonalkyl Tin Oxo Cluster and its Application as High EUV Absorption Coefficient and Etch Resistant Inorganic Resist for EUV Lithography.

We introduce a novel nonalkyl tin oxo cluster, CNU-TOC-01(4C-C), synthesized through a reflux-based solution reaction using SnCl, HO, and pyrazole, which permits scalable production and molecular customization. Using field desorption-time-of-flight mass spectrometry (FD-TOF MS) and small-angle X-ray scattering (SAXS), CNU-TOC-01(4C-C) is characterized as a cyclic cluster with the molecular formula SnCl(CNH)(CNH)HO. The cluster size was measured to be 11.

Tissue-resident CCR2 macrophage TREM-1/3 signaling is necessary for monocyte and neutrophil recruitment to injured hearts.

Triggering receptor expressed on myeloid cells 1 (TREM-1) has been shown to amplify inflammatory signals, such as Toll-like receptor signaling, after infection and sterile injury. While previous studies have demonstrated that TREM-1 activation in circulating immune cells promotes injury, the role of TREM-1 signaling in tissue-resident cells in the context of sterile inflammation remains poorly understood. Here, we used a cardiac transplantation model to dissect how Trem1/3 expression on heart-resident cells regulates sterile inflammation.

Epigenetic dynamics in meniscus cell migration and its zonal dependency in response to inflammatory conditions.

Meniscus injuries are challenging to treat due to the tissue heterogeneity and limited treatment efficacy. Understanding meniscus cell migration, crucial for healing, remains incomplete, especially its zonal dependency. This study explores how epigenetic mechanisms affect meniscus cell migration under inflammation, focusing on healing implications.

Aerobic biodegradation of micropollutants by nitrifiers and heterotrophs: Changes in biodegradation rate constant depending on levels of growth substrates and microbial activities.

This study investigated how the biodegradation rate constant (k) of 11 micropollutants (MPs) responded to changes in the concentrations of growth substrates and microbial activities while considering the predominant microbial degraders of MPs. Metformin, losartan, valsartan, and cimetidine (group A) were biodegraded predominantly by nitrifiers. MPs of group A showed a positive correlation with k and nitrifying activity, while a negative correlation was observed with the initial concentration of ammonium, possibly due to competitive inhibition.

Inflamed Tissue-Targeting Polyphenol-Condensed Antioxidant Nanoparticles with Therapeutic Potential.

Inflammation is essential for pathogen eradication and tissue repair; However, chronic inflammation can bring on multi-organ dysfunction due to an overproduction of reactive oxygen species (ROS). Among various anti-inflammatory agents, polyphenol-based nanotherapeutics offer potential advantages, including enhanced stability, targeted delivery, multiple therapeutic functions, and personalized therapy tailored to the severity. Despite these advantages, the development of biocompatible nanomedicines capable of selective accumulation in inflamed tissues and efficient inhibition of ROS-induced inflammatory signaling pathways remains a considerable challenge.

Mortality and cardiovascular disease after cholecystectomy in type 2 diabetes: A nationwide longitudinal cohort study.

Background: The long-term effects of cholecystectomy on mortality and cardiovascular disease (CVD) in patients with diabetes have not been evaluated. In the present study, we investigated the longitudinal effects of cholecystectomy on mortality and CVD in a population-based cohort with type 2 diabetes (T2D).

Methods: In total, 2 216 930 national health examination participants with T2D, including 19 258 patients with cholecystectomy, were followed up for a median of 7.

Patient-navigator working alliance and hepatitis C treatment cascade outcomes among persons who inject drugs: The HERO study.

Introduction: Integrating patient navigation (PN) interventions in hepatitis C virus (HCV) elimination efforts enhances HCV treatment cascade outcomes from screening to cure. Nonetheless, little is known about how the patient-navigator working alliance influences the effectiveness of PN interventions. This study among persons who inject drugs (PWID) living with HCV aimed to assess the association between patient-navigator working alliance and HCV treatment cascade outcomes.

Task-Oriented Channel Attention for Fine-Grained Few-Shot Classification.

The difficulty of fine-grained image classification mainly comes from a shared overall appearance across classes. Thus, recognizing discriminative details, such as the eyes and beaks of birds, is a key to the task. However, this is particularly challenging when training data is limited.

Managing Complex Hepatocellular Carcinoma Subtypes: Diffuse Infiltrative, Large Tumours, and Tumour Rupture-The Challenges and Strategies.

Hepatocellular carcinoma (HCC) is the sixth most common cause of cancer globally, third most common cause of cancer-related death, and most common primary liver malignancy. Whilst nodular well-defined HCC remains the classical phenotype, presentations with infiltrative phenotype, very large HCC, and complications as tumour rupture provide immense diagnostic and therapeutic challenges. Infiltrative HCC is difficult to distinguish against the background cirrhotic liver.

Enhanced model antigen retention in tissue through topical high-frequency ultrasound treatment.

Reproducible control of tissue delivery and retention of a therapeutic agent facilitates the maximization of the efficacy of pharmacotherapy. Despite the proposal of various chemical and physical methods for modulating drug delivery and retention, the choice of the physical modality for this purpose has been limited in clinical practice. Thus, this study proposes a novel strategy for modulating the retention of a model antigen in tissues by using non-tissue-damaging high-frequency ultrasoundAfter the injection of a fluorescently labeled model antigen, followed by brief treatment with high-frequency ultrasound (5-20 MHz), the clearance of the antigen was monitored using a real-time near-infrared (NIR) fluorescence imaging system in vivo.