Purpose: Levetiracetam is one of the most widely used antiepileptic drugs, but the evidence related to the safety of substitution from brand name to generic levetiracetam is scarce. The present study evaluated the risk of increased frequency of seizures after replacement of a brand-name levetiracetam with a generic product.
Methods: We enrolled patients with epilepsy who were treated with branded levetiracetam for at least 6 months of sustained use.