Publications by authors named "Sonya Prasad"
Article Synopsis
- After smallpox was eradicated, there have been more frequent small outbreaks of monkeypox (mpox), especially in Africa.
- The rapid spread of mpox in 2022 raises concerns of a potential second zoonotic pandemic in the 21st century.
- This article serves as a guide for dermatologists, covering the history, symptoms, complications, diagnosis, transmission, infection control, vaccination, and treatment options for mpox.
Article Synopsis
- * Data from 101 cases across 13 countries showed that skin lesions were often the first symptoms of infection, evolving from papules and vesicles to pustules and crusts/scabs as the infection progressed.
- * The research indicates notable differences from past outbreaks, including early skin lesions and a risk of scarring, while acknowledging potential biases in the registry data.
The World Health Organization declared the global monkeypox outbreak a public health emergency of international concern in July 2022. In response, the American Academy of Dermatology and International League of Dermatological Societies expanded the existing COVID-19 Dermatology Registry to become the "AAD/ILDS Dermatology COVID-19, Monkeypox, and Emerging Infections Registry." The goal of the registry is to rapidly collate cases of monkeypox and other emerging infections and enable prompt dissemination of findings to front-line healthcare workers and other members of the medical community.
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- Over the past decade, there's been increased focus on global health dermatology as skin conditions are a major nonfatal disease burden, often indicating severe illnesses.
- Dermatologists are active in four key areas: assessing the global burden of skin diseases, advocating for skin treatments in the World Health Organization's Essential Medicines list, developing programs for tropical diseases, and addressing skin issues related to COVID-19.
- Their efforts highlight the disproportionate impact of skin diseases on women and girls and contribute significantly to improving global health outcomes.
Article Synopsis
- Multiparametric MRI is commonly used for diagnosing prostate cancer, but it's unclear if all men with negative MRI results should still have a biopsy.
- Researchers aimed to create a prediction model to help identify which men with negative MRI results are at risk for prostate cancer (PCa), potentially avoiding unnecessary biopsies.
- The study involved analyzing data from 200 men with negative MRI and confirmed the model's effectiveness in predicting PCa using factors like PSA density, achieving a high accuracy with an area under the curve (AUC) of 0.80 for PCa and 0.87 for clinically significant PCa.
Article Synopsis
- Androgenetic alopecia (AGA) and acne vulgaris are common skin conditions influenced by androgens, leading to interest in topical antiandrogen therapies that may offer effective treatment with fewer side effects compared to systemic options.
- A literature review assessing topical treatments—finasteride, ketoconazole shampoo, and cortexolone 17α-propionate (C17P)—suggests that these therapies show promise, especially finasteride combined with minoxidil for AGA, while C17P may help with acne.
- Despite positive findings, further research is needed to confirm the safety and efficacy of these treatments, particularly with more female participants in clinical studies, as some therapies like topical finasteride are not safe during
Article Synopsis
- This study analyzed data from 536 patients who had robot-assisted laparoscopic radical prostatectomy to identify factors related to downgrading of Grade groups (GG) from biopsy to final pathology.
- Downgrading occurred in 14.1% of patients, with a higher rate in those undergoing fusion biopsy compared to standard biopsy (23.7% vs. 12.2%).
- Key factors linked to downgrading included the use of fusion biopsy and the maximum percentage of core involvement, but this downgrading did not significantly impact surgical outcomes.
Article Synopsis
- The study aimed to evaluate whether multiparametric MRI and genomic biomarkers could better identify patients with favorable intermediate-risk prostate cancer who are suitable for active surveillance.
- Researchers analyzed data from 509 patients who underwent surgery and tests, focusing on the predictive value of different factors for adverse pathology.
- The findings revealed that while certain factors were significant predictors of adverse pathology, the usefulness of multiparametric MRI was less clear, suggesting that genomic testing may provide better insights for patient management.
Article Synopsis
- The study investigates whether multiparametric magnetic resonance imaging (MRI) can predict aggressive prostate cancer features by analyzing records of 206 patients who underwent prostate surgery.
- Researchers found significant associations between the Prostate Imaging Reporting and Data System (PIRADS) score, lesion size, and extraprostatic extension with adverse pathology outcomes.
- Results suggest the PIRADS score may indicate increased metastatic risk, highlighting its potential prognostic utility in prostate cancer diagnosis and treatment planning.