Publications by authors named "Sonya B Polson"
J Pharmacol Exp Ther
December 2007
Article Synopsis
- - Xanomeline uniquely binds to the M1 muscarinic acetylcholine receptors by sticking not only to the main binding site but also to a secondary site, leading to prolonged receptor activation even after the drug is washed out.
- - A study showed that a 1-minute exposure to xanomeline caused a lasting decrease in [3H]N-methylscopolamine (NMS) binding, indicating a wash-resistant activation of the receptor.
- - After washing the cells and waiting 24 hours, the effects of xanomeline changed, revealing a two-phase binding curve that indicated a new, more potent binding state and suggesting that the initial brief exposure could lead to delayed receptor changes like desensitization or internal
