Publications by authors named "Sonya Abadali"
Article Synopsis
- The study evaluates the effectiveness of patient-derived organoids (PDOs) in predicting responses to neoadjuvant chemotherapy (NAT) in pancreatic adenocarcinoma patients.
- Researchers created a biobank of 136 samples, achieving successful PDO generation from a diverse group of patients, and found that the PDO responses could reflect pathological responses to NAT, particularly with oxaliplatin.
- The results highlight the feasibility of rapid PDO screening within a week of surgery, suggesting that these organoids could help personalize chemotherapy treatment for patients, improving initial treatment strategies.
Article Synopsis
- The study investigates how common genetic variants related to schizophrenia (SZ) interact to influence complex genetic disorders using human induced pluripotent stem cells (iPSCs).
- Researchers utilized CRISPR technology to focus on specific SZ-related genes and found that these genes impact neuronal function and gene expression differently based on cell type.
- The findings suggest that there is a significant interaction between common and rare genetic variants in contributing to the risk of psychiatric diseases, potentially applicable to other complex genetic disorders as well.
